Cell-based Kinase Targets Available

DiscoveRx offers a rapidly growing portfolio of cell-based kinase assays for detection of Receptor Tyrosine Kinase (RTK) and Cytosolic Tyrosine Kinase (CTK) signaling. Our panel of targets provides a unique opportunity to identify drug interactions by measuring either inhibition or activation in a physiologically relevant context.

Technology Overview

PathHunter cell-based kinase platform

Browse Available Cell-based Kinase Targets

Listed below are the cell-based kinase targets available for screening and profiling. Assays in the table may be sorted by column name. Contact us if you don't see your target of interest in our list below as additional catalog cell lines may be available for screening and profiling as a custom service.

Target Gene ▲	Common Name	Gene ID	GeneBank Accession No	Species
AXL	AXL	AXL receptor tyrosine kinase	NM_021913.3	Human
c-KIT	c-KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	NM_000222.2	Human
c-MET	C-MET	Hepatocyte growth factor receptor	NM_000245.2	Human
CSF3R		colony stimulating factor 3 receptor	NM_000760	Human
CSF3R-JAK1				Human
EphA5	EphA5	Ephrin type-A receptor 5	NM_004439	Human
EphA7	EphA7	Ephrin type-A receptor 7	NM_004440.3	Human
EphB2	EphB2	Ephrin type-B receptor 2	NM_017449.3	Human
EphB3	EphB3	Ephrin type-B receptor 3	NM_004443.3	Human
EphB4	EphB4	Ephrin type-B receptor 4	NM_004444	Human
ErbB1	EGFR	Receptor tyrosine-protein kinase erbB-1	NM_005228.3	Human
ErbB2	HER2	Receptor tyrosine-protein kinase erbB-2	NM_004448.2	Human
ErbB2/ErbB3	HER2/HER3	Receptor tyrosine-protein kinase erbB-2/erbB-3	NM_004448.2 & NM_001982.2	Human
ErbB4	HER4	Receptor tyrosine-protein kinase erbB-4	NM_005235.2	Human
GHR		Growth hormone receptor	NM_000163.2	Human
GHR-JAK1				Human
GHR-JAK2				Human
IGF1R	IGF1R	Insulin-like growth factor 1 receptor	NM_000875	Human
INSR	INSR	Insulin 1 receptor	NM_000208	Human
PDGFRA	PDGFRa	Platelet-derived growth factor receptor alpha	NM_006206.4	Human
PDGFRB	PDGFRb	Platelet-derived growth factor receptor beta	NM_005235	Human
PRLR	PRLR	Prolactin receptor	NM_000949	Human
PRLR-JAK1				Human
PRLR-JAK2				Human
SYK				Human
TrkA	NTRK1	Neurotrophic tyrosine kinase receptor type 1	NM_002529	Human
TrkA-p75	TrkA-p75	Neurotrophic tyrosine kinase receptor type 1 & p75 neurotrophin receptor	NM_002529	Human
TrkB	NTRK2	Neurotrophic tyrosine kinase receptor type 2	NM_006180	Human
TrkB-p75	TrkB-p75	Neurotrophic tyrosine kinase receptor type 2 & p75 neurotrophin receptor	NM_006180	Human
TrkC	NTRK3	Neurotrophic tyrosine kinase receptor type 3	NM_002530	Human
TrkC-p75	TrkC-p75	Neurotrophic tyrosine kinase receptor type 3 & p75 neurotrophin receptor	NM_002530	Human
TYK2				Human