Ortholog GPCR Assay List
DiscoveRx offers a comprehensive range of non-human ortholog GPCR assays to facilitate counterscreening and SAR evaluation of compounds identified in a primary screen using a human GPCR target. The DiscoveRx Services platform leverages this menu of GPCR assays for all screening and profiling services.
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Overview of Available Readout
Arrestin
Browse Available Ortholog GPCR Targets
Listed below are the assays currently available for screening and profiling. Assays may be sorted by column name.
Contact us if you don't see your target of interest in the list below as additional catalog assays may be available for screening and profiling as a custom service.
| Family ▲ | Target Gene | Common Name | Species | G protein coupling | Accession Number | Arrestin |
| 5-Hydroxytryptamine | mHTR2A | m5HT2A | Mouse | Gi/Go | NM_172812 | X |
| 5-Hydroxytryptamine | mHTR2C | m5HT2C | Mouse | Gi/Go | AF498983 | X |
| Acetylcholine | rCHRM4 | rM4 | Rat | Gs & Gi/Go | NM_000741 | X |
| Adenosine | mADORA2B | mA2B | Mouse | Gs | NM_007413 | X |
| Adenosine | mADORA3 | mA3 | Mouse | Gi/Go | NM_009631.3 | X |
| Anaphylatoxin | mC5AR1 | mC5AR | Mouse | Gi/Go | NM_007577.3 | X |
| Apelin | mAGTRL1 | mAPJ | Mouse | Gi/Go | NM_011784.2 | X |
| Cannabinoid | mCNR1 | mCB1 | Mouse | Gi/Go | NM_007726 | X |
| Cannabinoid | mCNR2 | mCB2 | Mouse | Gi/Go | NM_009924 | X |
| Chemokine | mCCR1 | mCC1 | Mouse | Gi/Go | NM_009912 | X |
| Chemokine | mCCR10 | mCCR10 | Mouse | Gi/Go | AY429103 | X |
| Chemokine | mCCR2 | mCCR2 | Mouse | Gi/Go | NM_009915.2 | X |
| Chemokine | mCCR3 | mCCR3 | Mouse | Gi/Go | NM_009914 | X |
| Chemokine | mCCR4 | mCCR4 | Mouse | Gi/Go | NM_006619 | X |
| Chemokine | mCCR5 | mCCR5 | Mouse | Gi/Go | NM_009917 | X |
| Chemokine | mCCR6 | mCCR6 | Mouse | Gi/Go | NM_009835.3 | X |
| Chemokine | mCCR7 | mCCR7 | Mouse | Gi/Go | NM_007719.2 | X |
| Chemokine | mCCR8 | mCCR8 | Mouse | Gi/Go | NM_007720.2 | X |
| Chemokine | mCMKLR1 | mCMKLR1 | Mouse | Gi/Go | NM_008153.2 | X |
| Chemokine | mCXCR2 | mCXCR2 | Mouse | Gi/Go | NM_009909 | X |
| Chemokine | mCXCR3 | mCXCR3 | Mouse | Gi/Go | NM_009910 | X |
| Chemokine | mCXCR4 | mCXCR4 | Mouse | Gi/Go | XM_001478244.1 | X |
| Chemokine | mCXCR5 | mCXCR5 | Mouse | Gi/Go | NM_007551 | X |
| Chemokine | mCXCR6 | mCXCR6 | Mouse | Gi/Go | NM_030712 | X |
| Chemokine | mCXCR7 | mCXCR7 | Mouse | None | NM_007722 | X |
| Chemokine | mCCR9 | mCCR9 | Mouse | Gi/Go | NM_007713.5 | X |
| Class A Orphan | mGPR1 | mGPR1 | Mouse | Unknown | NM_146250 | X |
| Class A Orphan | mGPR120 | mGPR120 | Mouse | Unknown | NM_181748 | X |
| Corticotropin | mCRHR1 | mCRF1 | Mouse | Gs | NM_007762 | X |
| Dopamine | mDRD5 | mDRD5 | Mouse | Gs | NM_013503.2 | X |
| Dopamine | rDRD2L | rD2L | Rat | Gi/Go | NM_012547.1 | X |
| Dopamine | rDRD2S | rD2S | Rat | Gi/Go | NM_016574.3 | X |
| Dopamine | rDRD5 | rD5 | Rat | Gs | NM_000798.3 | X |
| Endothelin | mEDNRA | mETA | Mouse | Gq | NM_010332.2 | X |
| Endothelin | mEDNRB | mETB | Mouse | Gi/Go & Gs | NM_007904.3 | X |
| Formylpeptide | mFPR1 | mFPR1 | Mouse | Gq | NM_013521.2 | X |
| Galanin | mGALR2 | mGALR2 | Mouse | Gi/Go | NM_010254.4 | X |
| Ghrelin | mGHSR1a | ghrelin | Mouse | Gq | NM_177330 | X |
| Glucagon | mGCGR | glucagon | Mouse | Gs | NM_008101.2 | X |
| Glucagon | mGIPR | mGIP | Mouse | Gs | NM_001080815.1 | X |
| Glucagon | mGLP1R | mGLP-1 | Mouse | Gs | NM_021332 | X |
| Leukotriene | mLTB4R | mBLT1 | Mouse | Gi/Go & Gq | NM_008519.2 | X |
| Lysophospholipid | cEDG5 | cS1P2 | Canine | Gs | XM_542076.2 | X |
| Lysophospholipid | mEDG1 | mS1P1 | Mouse | Gi/Go | NM_007901 | X |
| Lysophospholipid | mEDG5 | mS1P2 | Mouse | Gs | NM_010333.4 | X |
| Lysophospholipid | mEDG6 | mS1P4 | Mouse | Gq | NM_010102.2 | X |
| Lysophospholipid | rEDG5 | rS1P2 | Rat | Gs | NM_017192.2 | X |
| Lysophospholipid | sEDG5 | sS1P2 | Simian | Gs | XM_001100481.1 | X |
| Melanin-concentrating hormone | mMCHR1 | MCH1 | Mouse | Gi/Go | NM_145132 | X |
| Neuropeptide Y | mNPY1R | Y1 | Mouse | Gi/Go | NM_010934.4 | X |
| Neuropeptide Y | mNPY2R | NPY2R | Mouse | Gi/Go & Gq | NM_008731.3 | X |
| Neuropeptide Y | mPPYR1 | Y4 | Mouse | Gi/Go | NM_008919.4 | X |
| Opioid | mOPRD1 | δ (murine) | Mouse | Gi/Go | NM_013622.3 | X |
| Opioid | mOPRK1 | κ (murine) | Mouse | Gi/Go | NM_011011 | X |
| Opioid | mOPRM1 | μ (murine) | Mouse | Gi/Go | NM_001039652 | X |
| Opioid | rOPRM1 | μ | Rat | Gi/Go | NM_013071 | X |
| Orexin | mHCRTR1 | mOX1 | Mouse | Gq | AY062030 | X |
| P2Y | mP2RY12 | mP2Y12 | Mouse | Gi/Go | NM_027571.3 | X |
| P2Y | mP2RY6 | P2Y6 | Mouse | Gq | NM_183168.1 | X |
| Platelet-activating factor | mPTAFR | mPAF | Mouse | Gi/Go & Gq | NM_001081211.1 | X |
| Prokineticin | rPROKR1 | rPROKR1 | Rat | Gs & Gq | | X |
| Prokineticin | rPROKR2 | rPKR2 | Rat | Gs | NM_138978 | X |
| Prostanoid | mCRTH2 | mDP2 | Mouse | Gi/Go | NM_009962.2 | X |
| Prostanoid | rCRTH2 | rGPR44 | Rat | Gi/Go | NM_001012070.1 | X |
| Somatostatin | mSSTR2 | mSST2 | Mouse | Gi/Go | NM_001042606.1 | X |
| Somatostatin | mSSTR5 | mSRIF1B | Mouse | Gi/Go | NM_011425.2 | X |
| Urotensin | mUTR2 | mUT | Mouse | Gq | NM_145440 | X |
| Vasopressin and Oxytocin | mOXTR1 | mOT | Mouse | Gq | NM_001081147.1 | X |
| VIP and PACAP | mADCYAP1R1 | mPAC1 | Mouse | Gs & Gq | NM_001025372.1 | X |
| VIP and PACAP | mVIPR1 | mVPAC1 | Mouse | Gs | NM_011703.4 | X |