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Orphan GPCR Assay List

DiscoveRx offers a comprehensive range of assays for detection of GPCR signaling through β-Arrestin recruitment. Since Arrestin recruitment occurs independent of G-protein coupling, these assays provide a direct, universal platform for measuring receptor activation making this the ideal platform to rapidly de-orphanize receptors. The DiscoveRx Services platform leverages this menu of GPCR assays for all screening and profiling services.

Overview of Available Readout

Arrestin

Browse Available Orphan GPCR Targets

Listed below are the assays currently available for screening and profiling. Assays may be sorted by column name. Contact us if you don't see your target of interest in the list below as additional catalog assays may be available for screening and profiling as a custom service.

Family ▲	Target Gene	Common Name	Species	G protein coupling	Accession Number	Arrestin
Class A Orphan	CCRL2	CCRL2	Human	Unknown	NM_003965	X
Class A Orphan	GHSR1b	GHSR1b	Human	Unknown	NM_004122	X
Class A Orphan	GPR101	GPR101	Human	Unknown	NM_054021	X
Class A Orphan	GPR12	GPR12	Human	Unknown	NM_005288	X
Class A Orphan	GPR132	GPR132	Human	Unknown	NM_013345	X
Class A Orphan	GPR135	GPR135	Human	Unknown	NM_022571	X
Class A Orphan	GPR139	GPR139	Human	Unknown	NM_171791	X
Class A Orphan	GPR141	GPR141	Human	Unknown	NM_181791	X
Class A Orphan	GPR142	GPR142	Human	Unknown	NM_181790	X
Class A Orphan	GPR146	GPR146	Human	Unknown	NM_138445	X
Class A Orphan	GPR148	GPR148	Human	Unknown	XM_293092	X
Class A Orphan	GPR149	GPR149	Human	Unknown	XM_293580	X
Class A Orphan	GPR15	GPR15	Human	Unknown	NM_005290.1	X
Class A Orphan	GPR150	GPR150	Human	Unknown	XM_209675	X
Class A Orphan	GPR151	GPR151	Human	Unknown	NM_194251	X
Class A Orphan	GPR152	GPR152	Human	Unknown	XM_352045	X
Class A Orphan	GPR161	GPR161	Human	Unknown	NM_153832.1	X
Class A Orphan	GPR162	GPR162	Human	Unknown	NM_019858	X
Class A Orphan	GPR17	GPR17	Human	Unknown	NM_005291	X
Class A Orphan	GPR171	GPR171	Human	Unknown	NM_013308	X
Class A Orphan	GPR173	GPR173	Human	Unknown	NM_018969	X
Class A Orphan	GPR176	GPR176	Human	Unknown	NM_007223	X
Class A Orphan	GPR18	GPR18	Human	Unknown	NM_005292	X
Class A Orphan	GPR182	GPR182	Human	Unknown	NM_007264	X
Class A Orphan	GPR20	GPR20	Human	Unknown	NM_005293	X
Class A Orphan	GPR23	LPA4	Human	Unknown	NM_005296	X
Class A Orphan	GPR25	GPR25	Human	Unknown	NM_005298	X
Class A Orphan	GPR26	GPR26	Human	Unknown	NM_153442	X
Class A Orphan	GPR27	GPR27	Human	Unknown	NM_018971	X
Class A Orphan	GPR3	GPR3	Human	Unknown	NM_005281	X
Class A Orphan	GPR31	GPR31	Human	Unknown	NM_005299	X
Class A Orphan	GPR32	GPR32	Human	Unknown	NM_001506	X
Class A Orphan	GPR37	EDNRBL	Human	Unknown	NM_005302	X
Class A Orphan	GPR37L1	GPR37L1	Human	Unknown	NM_004767	X
Class A Orphan	GPR39	GPR39	Human	Gq	NM_001508	X
Class A Orphan	GPR4	GPR4	Human	Unknown	NM_005282	X
Class A Orphan	GPR45	GPR45	Human	Unknown	NM_007227	X
Class A Orphan	GPR50	GPR50	Human	Unknown	NM_004224	X
Class A Orphan	GPR52	GPR52	Human	Unknown	NM_005684	X
Class A Orphan	GPR6	GPR6	Human	Unknown	NM_005284	X
Class A Orphan	GPR61	GPR61	Human	Unknown	NM_031936	X
Class A Orphan	GPR65	GPR65	Human	Unknown	NM_003608	X
Class A Orphan	GPR75	GPR75	Human	Unknown	NM_006794	X
Class A Orphan	GPR78	GPR78	Human	Unknown	NM_080819	X
Class A Orphan	GPR79	GPR79	Human	Unknown	NM_001272	X
Class A Orphan	GPR83	GPR83	Human	Unknown	NM_016540	X
Class A Orphan	GPR85	GPR85	Human	Unknown	NM_018970	X
Class A Orphan	GPR88	GPR88	Human	Unknown	NM_022049	X
Class A Orphan	LGR4	LGR4	Human	Unknown	NM_018490	X
Class A Orphan	LGR5	LGR5	Human	Unknown	NM_003667	X
Class A Orphan	LGR6	LGR6	Human	Unknown	XM_097508	X
Class A Orphan	MRGPRD	MRGPRD	Human	Unknown	NM_198923	X
Class A Orphan	MRGPRE	MRGPRE	Human	Unknown	XM_171536	X
Class A Orphan	MRGPRF	MRGPRF	Human	Unknown	NM_145015	X
Class A Orphan	MRGPRX1	MRGPRX1	Human	Gq	NM_147199	X
Class A Orphan	MRGPRX4	MRGPRX4	Human	Unknown	NM_054032	X
Class A Orphan	OPN5	OPN5	Human	Unknown	NM_181744.2	X
Class A Orphan	OXGR1	OXGR1	Human	Gq	NM_080818.3	X
Class A Orphan	P2RY8	P2RY8	Human	Unknown	NM_178129	X
Class A Orphan	TAAR5	TAAR5	Human	Unknown	NM_003967.2	X
Class B Orphan	BAI1	BAI1	Human	unknown	NM_001702.2	X
Class B Orphan	BAI2	BAI2	Human	unknown	NM_001703.2	X
Class B Orphan	BAI3	BAI3	Human	unknown	NM_001704.2	X
Class B Orphan	GPR123	GPR123	Human	Unknown	NM_001083909	X
Class B Orphan	GPR157	GPR157	Human	Unknown	NM_024980	X
Class B Orphan	GPR97	GPR97	Human	Unknown	NM_170776	X
Estrogen (G protein coupled) receptor	GPR30	GPER	Human	Gi/Go & Gs	NM_001505	X
Non-signalling 7TM chemokine-binding proteins	DARC	FY	Human	Unknown	NM_002027	X
Other 7TM proteins	GPR107	GPR107	Human	Unknown	NM_020960	X
Other 7TM proteins	GPR137	TM7SF1	Human	Unknown	NM_003272	X
Other 7TM proteins	GPR143	GPR143	Human	Unknown	NM_000273	X
Peptide P518 receptor	GPR103	QRFPR	Human	Gq	NM_198179	X

Orphan GPCR Assay List

Overview of Available Readout

Browse Available Orphan GPCR Targets