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Known GPCR Assay List

DiscoveRx offers an industry leading portfolio of non-force coupled GPCR cell lines designed to detect different GPCR signaling through arrestin recruitment, second messenger signaling and receptor internalization. Access to the same receptor in different technology formats allows multiple signaling pathways to be assayed in parallel and enables the identification of novel biased ligands and characterization of novel drug interactions. The DiscoveRx Services platform leverages this menu of GPCR assays for all screening and profiling services.

Overview of Available Readouts

Arrestin
Second messenger (cAMP & Calcium)
Internalization

Browse Available Known GPCR Targets

Listed below are the assays currently available for screening and profiling. Assays may be sorted by column name. Contact us if you don't see your target of interest in the list below as additional catalog assays may be available for screening and profiling as a custom service. Note: Standard Known GPCR Profile Panel includes Arrestin assays only. Additional known GPCR assays (non-Arrestin) available as a custom panel request.

Family	Target Gene	Common Name	Species	G protein coupling	Accession Number	Arrestin	cAMP	Calcium	Internalization
5-Hydroxytryptamine	HTR1A	5HT1A	Human	Gi/Go	NM_000524.2	X	X
5-Hydroxytryptamine	HTR1B	5HT1B	Human	Gi/Go	NM_000863	X	X
5-Hydroxytryptamine	HTR1E	5HT1E	Human	Gi/Go	NM_000865	X
5-Hydroxytryptamine	HTR1F	5HT1F	Human	Gi/Go	NM_000866.3	X	X
5-Hydroxytryptamine	HTR2A	5HT2A	Human	Gq	NM_000621.3	X		X	X
5-Hydroxytryptamine	HTR2B*	5HT2B	Human	Gq	NM_000867.4			X
5-Hydroxytryptamine	HTR2C	5HT2C	Human	Gq	AF498983	X		X	X
5-Hydroxytryptamine	HTR5A	5HT5A	Human	Gi/Go	NM_024012	X	X
5-Hydroxytryptamine	HTR7A*	5HT7A	Human	Gs	NM_000872.4		X
5-Hydroxytryptamine	HTR7B*	5HT7B	Human	Gs	NM_019860.3		X
5-Hydroxytryptamine	HTR7D*	5HT7D	Human	Gs	NM_000872		X
Acetylcholine	CHRM1	M1	Human	Gq	AF498915	X		X	X
Acetylcholine	CHRM2	M2	Human	Gi/Go	AF498916	X	X		X
Acetylcholine	CHRM3	M3	Human	Gq	AF498917	X		X	X
Acetylcholine	CHRM4	M4	Human	Gs & Gi/Go	NM_000741.2	X	X
Acetylcholine	CHRM5	M5	Human	Gq	AF498919	X		X	X
Adenosine	ADORA1	A1	Human	Gi/Go	AY136746	X	X	X
Adenosine	ADORA2A*	A2A	Human	Gs & Gq	NM_000675.4			X
Adenosine	ADORA2B	A2B	Human	Gs	AY136748	X	X
Adenosine	ADORA3	A3	Human	Gi/Go	NM_000677.3	X	X
Adrenergic	ADRA2C	α2C-adrenoreceptor	Human	Gi/Go	NM_000683	X	X
Adrenergic	ADRB1	β1-adrenoreceptor	Human	Gs	NM_000684	X	X
Adrenergic	ADRB2	β2-adrenoreceptor	Human	Gs	NM_000024	X	X		X
Adrenergic	ADRB3*	β3-adrenoreceptor	Human	Gs	NM_000025		X
Adrenergic	ADRA1A*	α1A-adrenoreceptor	Human	Gq	NM_000680			X
Adrenergic	ADRA1B	α1B-adrenoreceptor	Human	Gq	NM_000679	X		X
Adrenergic	ADRA2A	α2A-adrenoreceptor	Human	Gi/Go	NM_000681	X	X
Adrenergic	ADRA2B	α2B-adrenoreceptor	Human	Gi/Go	NM_000682.5	X
Anaphylatoxin	C3AR1	C3A	Human	Gi/Go	NM_004054.2	X	X		X
Anaphylatoxin	C5AR1	C5A	Human	Gi/Go	NM_001736	X	X		X
Anaphylatoxin	C5L2	C5L2	Human	None	NM_018485.1	X			X
Angiotensin	AGTR1	AT1	Human	Gq	NM_000685	X		X
Apelin	AGTRL1	APJ	Human	Gi/Go	NM_005161	X	X		X
Bile acid	GPBAR1	GPBA	Human	Gs	NM_001077194.1	X	X
Bombesin	BRS3	BB3	Human	Gq	NM_001727	X		X
Bombesin	GRPR	BB2	Human	Gq	NM_005314	X		X	X
Bradykinin	BDKRB1	B1	Human	Gq	NM_000710.2	X		X
Bradykinin	BDKRB2	B2	Human	Gq	NM_000623.3	X		X	X
Calcitonin	CALCR	CT	Human	Gs	NM_001742.2	X	X
Calcitonin	CALCR + RAMP1*	AMY1	Human	Gs	NM_001742.2		X
Calcitonin	CALCR + RAMP2	AMY2	Human	Gs	NM_001742.2	X
Calcitonin	CALCR + RAMP3	AMY3	Human	Gs	NM_001742.2	X	X
Calcitonin	CALCRL + RAMP1	CGRP	Human	Gs	AY389506	X	X
Calcitonin	CALCRL + RAMP2	AM1	Human	Gs	AY389506	X	X
Calcitonin	CALCRL + RAMP3	AM2	Human	Gs	AY389506	X	X
Calcium sensing	CASR*	CaS	Human	Gq & Gi/Go	NM_000388.3			X
Cannabinoid	CNR1	CB1	Human	Gi/Go	AY225225	X	X
Cannabinoid	CNR2	CB2	Human	Gi/Go	AY242132	X	X
Chemokine	CCR1	CCR1	Human	Gi/Go	NM_001295	X	X		X
Chemokine	CCR10	CCR10	Human	Gi/Go	AY429103	X	X		X
Chemokine	CCR2	CCR2	Human	Gi/Go	NM_001123396	X			X
Chemokine	CCR3	CCR3	Human	Gi/Go	NM_001837	X
Chemokine	CCR4	CCR4	Human	Gi/Go	AY322539	X			X
Chemokine	CCR5	CCR5	Human	Gi/Go	BC038398	X	X		X
Chemokine	CCR6	CCR6	Human	Gi/Go	AY242126	X	X		X
Chemokine	CCR7	CCR7	Human	Gi/Go	AY587876	X	X		X
Chemokine	CCR8	CCR8	Human	Gi/Go	NM_005201.3	X
Chemokine	CCR9	CCR9	Human	Gi/Go	AY242127	X
Chemokine	CMKLR1	CMKLR1	Human	Gi/Go	NM_004072.2	X	X
Chemokine	CX3CR1	CX3CR1	Human	Gi/Go	NM_001337	X
Chemokine	CXCR1	CXCR1	Human	Gi/Go	NM_000634	X	X		X
Chemokine	CXCR2	CXCR2	Human	Gi/Go	NM_001557	X	X		X
Chemokine	CXCR3	CXCR3	Human	Gi/Go	AY242128	X	X		X
Chemokine	CXCR4	CXCR4	Human	Gi/Go	AY242129	X	X
Chemokine	CXCR5	CXCR5	Human	Gi/Go	NM_001716	X	X
Chemokine	CXCR6	CXCR6	Human	Gi/Go	AY322543	X	X		X
Chemokine	CXCR7	CXCR7	Human	None	NM_020311.2	X			X
Chemokine	XCR1	XCR1	Human	Gi/Go	NM_005283	X	X
Cholecystokinin	CCKAR	CCK1	Human	Gq	AY322549	X		X	X
Cholecystokinin	CCKBR	CCK2	Human	Gq	AY322551	X		X	X
Class A Orphan	EBI2	GPR183	Human	Gi/Go	NM_080818	X
Class A Orphan	GPR1	GPR1	Human	N/A	NM_005279	X			X
Class A Orphan	GPR119	GPR119	Human	Unknown	NM_178471	X
Class A Orphan	GPR120	GPR120	Human	Unknown	NM_181745	X			X
Class A Orphan	GPR35	GPR35	Human	Gi/Go	NM_005301	X	X
Class A Orphan	GPR55	GPR55	Human	Unknown	NM_005683.3	X
Class A Orphan	GPR84	GPR84	Human	Gi/Go	NM_020370	X	X
Class A Orphan	GPR91	SUCNR1	Human	Unknown	NM_033050	X
Class A Orphan	GPR92	GPR92	Human	Gq	NM_020400	X		X
Class A Orphan	MRGPRX2	MRGX2	Human	Gq	NM_054030	X		X
Corticotropin	CRHR1	CRF1	Human	Gs	AY457172	X	X		X
Corticotropin	CRHR2	CRF2	Human	Gs	AY449734	X	X
Dopamine	DRD1	D1	Human	Gs	NM_000794.3	X	X
Dopamine	DRD2L	D2L	Human	Gi/Go	NM_000795.3	X	X
Dopamine	DRD2S	D2S	Human	Gi/Go	NM_016574.3	X	X
Dopamine	DRD3	D3	Human	Gi/Go	NM_000796.3	X
Dopamine	DRD4	D4	Human	Gi/Go	NM_000797.2	X	X
Dopamine	DRD5	D5	Human	Gs	NM_000798.3	X	X
Endothelin	EDNRA	ETA	Human	Gq	AY275462	X		X
Endothelin	EDNRB	ETB	Human	Gs & Gi/Go	NM_000115.2	X			X
Formylpeptide	FPR1	FPR1	Human	Gi/Go	NM_002029	X	X		X
Formylpeptide	FPRL1	FPR2/ALX	Human	Gi/Go	AY225226	X	X		X
Free Fatty Acid	FFAR1	FFA1	Human	Gq	NM_005303.2	X		X
Free Fatty Acid	FFAR2*	GPR43	Human	Gq & Gi/Go	NM_005306.2			X
Free Fatty Acid	FFAR3*	GPR41	Human	Gi/Go	NM_005304.3		X
GABAB	GABBR1*	GABB1	Human	N/A	NM_021903.2		X
Galanin	GALR1	GALR1	Human	Gi/Go	AY541036	X	X		X
Galanin	GALR2	GALR2	Human	Gq & Gs	NM_003857	X	X	X
Ghrelin	GHSR1a	ghrelin	Human	Gq	NM_198407	X		X
Glucagon	GCGR	glucagon	Human	Gs	NM_000160	X	X		X
Glucagon	GHRHR*	GHRH	Human	Gs	NM_000823.2		X
Glucagon	GIPR	GIP	Human	Gs	NM_000164	X	X		X
Glucagon	GLP1R	GLP-1	Human	Gs	BC112126	X	X		X
Glucagon	GLP2R	GLP-2	Human	Gs	NM004246.1	X	X		X
Glucagon	SCTR	secretin	Human	Gs	AY462218	X	X		X
Glutamate	GRM1*	mGlu1	Human	Gq	NM_000838.2			X
Glutamate	GRM2*	mGlu2	Human	Gi/Go	NM_000839		X
Glutamate	GRM3*	MGlu3	Human	Gi/Go	NM_000840.2		X
Glutamate	GRM4*	mGlu4	Human	Gi/Go	NM_000841		X
Glutamate	GRM6*	mGlu6	Human	Gi/Go	NM_000843		X
Glycoprotein hormone receptor	FSHR	FSHR	Human	Gs	NM_000145	X	X
Glycoprotein hormone receptor	LHCGR	LH	Human	Gs	NM_000233	X	X
Glycoprotein hormone receptor	TSHR(L)	TSH	Human	Gs	NM_000369.2	X	X
Gonadotropin-releasing hormone	GNRHR*	GnRH	Human	Gq	NM_000406.2			X
Histamine	HRH1	H1	Human	Gq	AY136743	X		X
Histamine	HRH2	H2	Human	Gs	AY136744	X	X
Histamine	HRH3	H3	Human	Gi/Go	NM_007232	X	X
Histamine	HRH4	H4	Human	Gi/Go	NM_021624	X
Hydroxycarboxylic acid	GPR109A	HCA2	Human	Gi/Go	NM_177551	X	X
Hydroxycarboxylic acid	GPR109B	HCA3	Human	Gi/Go	NM_006018	X	X
Hydroxycarboxylic acid	GPR81	HCA1	Human	Gi/Go	NM_032554	X	X
Kisspeptin receptor	KISS1R	kisspeptin	Human	Gq	NM_032551	X
Leukotriene	LTB4R	BLT1	Human	Gi/Go & Gq	AY322535	X	X	X	X
Leukotriene	OXER1*	OXE	Human	Gi/Go	NM_148962.4		X
Leukotriene	CYSLTR2*	CYSLT2	Human	Gq	NM_020377.2			X
Lysophospholipid	EDG1	S1P1	Human	Gi/Go	NM_001400	X	X		X
Lysophospholipid	EDG2	LPA1	Human	Gi/Go	NM_001401.3	X			X
Lysophospholipid	EDG3	S1P3	Human	Gq	NM_005226	X		X	X
Lysophospholipid	EDG4	LPA2	Human	Gq	AY322548	X		X
Lysophospholipid	EDG5	S1P2	Human	Gs	NM_004230.3	X			X
Lysophospholipid	EDG6	S1P4	Human	Gq	AY322537	X
Lysophospholipid	EDG7	LPA3	Human	Gq	NM_012152.2	X		X	X
Lysophospholipid	EDG8	S1P5	Human	Gi/Go	NM_030760.4	X
Melanin-concentrating hormone	MCHR1	MCH1	Human	Gi/Go	AY562945	X	X
Melanin-concentrating hormone	MCHR2	MCH2	Human	Gq	NM_000706.3	X		X
Melanocortin	MC1R	MC1	Human	Gs	NM_002386	X	X
Melanocortin	MC3R	MC3	Human	Gs	AY227893	X	X		X
Melanocortin	MC4R	MC4	Human	Gs	AY236539	X	X
Melanocortin	MC5R	MC5	Human	Gs	NM_005913	X	X
Melatonin	MTNR1A	MT1	Human	Gi/Go	NM_005958	X	X
Melatonin	MTNR1B	MT2	Human	Gi/Go	NM_005959.3	X	X
Motilin	MLNR	motilin	Human	Gq	AY603964	X		X	X
Neuromedin U	NMU1R	NMU1	Human	Gq	NM_006056	X		X	X
Neuropeptide B & W	NPBWR1	NPBW1	Human	Gi/Go	NM_005285	X	X
Neuropeptide B & W	NPBWR2	NPBW2	Human	Gi/Go	NM_005286	X	X
Neuropeptide F	NPFFR1	NPFF1	Human	Gi/Go	NM_022146	X	X
Neuropeptide F	NPFFR2*	NPFF2	Human	Gi/Go	NM_053036.2		X
Neuropeptide S	NPSR1B	NPS receptor	Human	Gq	NM_207172	X
Neuropeptide Y	NPY1R	Y1	Human	Gi/Go	AY548168	X	X
Neuropeptide Y	NPY2R	Y2	Human	Gi/Go	AY236540	X	X	X	X
Neuropeptide Y	PPYR1	Y4	Human	Gi/Go	AY268432	X	X
Neurotensin	NTSR1	NTS1	Human	Gq	AY429106	X		X	X
Opioid	OPRD1	δ	Human	Gi/Go	NM_000911	X	X		X
Opioid	OPRK1	κ	Human	Gi/Go	AF498922	X	X		X
Opioid	OPRL1	NOP	Human	Gi/Go	AY268428	X	X
Opioid	OPRM1	μ	Human	Gi/Go	NM_000914.3	X	X		X
Orexin	HCRTR1	OX1	Human	Gq	NM_001525.2	X		X	X
Orexin	HCRTR2	OX2	Human	Gq	AF041245	X		X	X
P2Y	P2RY1	P2RY1	Human	Gq	NM_002563.2	X		X
P2Y	P2RY11	P2Y11	Human	Gs & Gq	AY449733	X		X	X
P2Y	P2RY12	P2Y12	Human	Gi/Go	AY136754	X
P2Y	P2RY2	P2Y2	Human	Gq	AY136753	X		X	X
P2Y	P2RY4	P2Y4	Human	Gq	NM_002565	X		X	X
P2Y	P2RY6	P2Y6	Human	Gq	NM_004154	X
Parathyroid	PTHR1	PTH1	Human	Gs & Gq	AY449732	X	X	X	X
Parathyroid	PTHR2	PTH2	Human	Gs	AY497546	X	X	X	X
Platelet-activating factor	PTAFR	PAF	Human	Gi/Go & Gq	AY275466	X	X	X	X
Prokineticin	PROKR1	PKR1	Human	Gs & Gq	NM_138964	X	X	X	X
Prokineticin	PROKR2	PKR2	Human	Gs	NM_144773	X			X
Prolactin releasing peptide receptor	PRLHR	PRRP	Human	Gq	NM_004248	X		X	X
Prostanoid	PTGER2	EP2	Human	Gs	AY275471	X
Prostanoid	PTGER3	EP3	Human	Gi/Go & Gq	NM_198716	X	X	X
Prostanoid	PTGER4	EP4	Human	Gs	AY429109	X			X
Prostanoid	PTGFR	FP	Human	Gq	NM_000959.3	X		X	X
Prostanoid	PTGIR	IP1	Human	Gs	AY242134	X	X		X
Prostanoid	TBXA2R	TP	Human	Gq	NM_001060	X		X
Prostanoid	CRTH2	DP2	Human	Gi/Go	AY507142	X	X
Prostanoid	PTGDR*	DP1	Human	Gs	NM_000953		X
Prostanoid	PTGER1	EP1	Human	Gq	NM_000955.2	X		X
Protease activated	F2R	PAR1	Human	Gi/Go	BC002464	X		X
Protease activated	F2RL1	PAR2	Human	Gi/Go & Gq	NM_005242.4	X		X	X
Protease activated	F2RL3	PAR4	Human	Gi/Go & Gq	AY431102	X		X	X
Relaxin	RXFP1*	RXFP1	Human	Gs	NM_021634.2		X
Relaxin	RXFP3	RXFP3	Human	Gi/Go	NM_016568.2	X	X
Relaxin	RXFP4	RXFP4	Human	Gi/Go	NM_181885.2	X	X	X
Somatostatin	SSTR1	SST1	Human	Gi/Go	NM_001049	X
Somatostatin	SSTR2	SST2	Human	Gi/Go	AY236542	X	X		X
Somatostatin	SSTR3	SST3	Human	Gi/Go	AY322541	X	X
Somatostatin	SSTR4	SST4	Human	Gi/Go	AY548169	X	X
Somatostatin	SSTR5	SST5	Human	Gi/Go	NM_001053	X	X
Tachykinin	TACR1	NK1	Human	Gq	NM_001058	X		X	X
Tachykinin	TACR2	NK2	Human	Gq	AY322545	X		X	X
Tachykinin	TACR3	NK3	Human	Gs & Gq	NM_001059	X	X	X	X
TRH	TRHR	TRH1	Human	Gq	AY493373	X		X
Urotensin	UTR2	UT	Human	Gq	NM_018949	X		X	X
Vasopressin and Oxytocin	AVPR1A	V1A	Human	Gq	NM_000706.3	X		X	X
Vasopressin and Oxytocin	AVPR1B	V1B	Human	Gq	NM_000707.3	X		X	X
Vasopressin and Oxytocin	AVPR2	V2	Human	Gs	NM_000054.4	X	X		X
Vasopressin and Oxytocin	OXTR	OT	Human	Gq	AY389507	X		X	X
VIP and PACAP	ADCYAP1R1	PAC1	Human	Gs & Gq	AY366498	X	X	X	X
VIP and PACAP	VIPR1	VPAC1	Human	Gs & Gq	NM_004624	X	X		X
VIP and PACAP	VIPR2	VPAC2	Human	Gs	NM_003382	X	X		X

Known GPCR Assay List

Overview of Available Readouts

Browse Available Known GPCR Targets