Explore our GPCR Assays

View our comprehensive panel of available GPCR targets

DiscoveRx offers a comprehensive portfolio of cell-based and biochemical assay formats against a broad range of target classes. View available assays and assay panels below. Don't see the assay you need? Contact us if you don't see your target of interest in our list below as additional catalog items may be available for screening and profiling as a custom service.

Overview of Available Readouts

Arrestin
Second messenger (cAMP & Calcium)
Internalization

View Available GPCR Panels

Known GPCR
Orphan GPCR
Ortholog
Therapeutic GPCR Panels

Browse Available GPCR Targets

Listed below are the assays currently available for screening and profiling. Assays may be sorted by column name. Contact us if you don't see your target of interest in list below as additional catalog assays may be available for screening and profiling as a custom service.

Family	Target Gene	Common Name	Species	G protein coupling	Accession Number	Arrestin	cAMP	Calcium	Internalization
5-Hydroxytryptamine	mHTR2A	m5HT2A	Mouse	Gi/Go	NM_172812	X
5-Hydroxytryptamine	mHTR2C	m5HT2C	Mouse	Gi/Go	AF498983	X
5-Hydroxytryptamine	HTR1A	5HT1A	Human	Gi/Go	NM_000524.2	X	X
5-Hydroxytryptamine	HTR1B	5HT1B	Human	Gi/Go	NM_000863	X	X
5-Hydroxytryptamine	HTR1E	5HT1E	Human	Gi/Go	NM_000865	X
5-Hydroxytryptamine	HTR1F	5HT1F	Human	Gi/Go	NM_000866.3	X	X
5-Hydroxytryptamine	HTR2A	5HT2A	Human	Gq	NM_000621.3	X		X	X
5-Hydroxytryptamine	HTR2B	5HT2B	Human	Gq	NM_000867.4			X
5-Hydroxytryptamine	HTR2C	5HT2C	Human	Gq	AF498983	X		X	X
5-Hydroxytryptamine	HTR5A	5HT5A	Human	Gi/Go	NM_024012	X	X
5-Hydroxytryptamine	HTR7A	5HT7A	Human	Gs	NM_000872.4		X
5-Hydroxytryptamine	HTR7B	5HT7B	Human	Gs	NM_019860.3		X
5-Hydroxytryptamine	HTR7D	5HT7D	Human	Gs	NM_000872		X
Acetylcholine	rCHRM4	rM4	Rat	Gs & Gi/Go	NM_000741	X
Acetylcholine	CHRM1	M1	Human	Gq	AF498915	X		X	X
Acetylcholine	CHRM2	M2	Human	Gi/Go	AF498916	X	X		X
Acetylcholine	CHRM3	M3	Human	Gq	AF498917	X		X	X
Acetylcholine	CHRM4	M4	Human	Gs & Gi/Go	NM_000741.2	X	X
Acetylcholine	CHRM5	M5	Human	Gq	AF498919	X		X	X
Adenosine	mADORA2B	mA2B	Mouse	Gs	NM_007413	X
Adenosine	mADORA3	mA3	Mouse	Gi/Go	NM_009631.3	X
Adenosine	ADORA1	A1	Human	Gi/Go	AY136746	X	X	X
Adenosine	ADORA2A	A2A	Human	Gs & Gq	NM_000675.4			X
Adenosine	ADORA2B	A2B	Human	Gs	AY136748	X	X
Adenosine	ADORA3	A3	Human	Gi/Go	NM_000677.3	X	X
Adrenergic	ADRA2C	α2C-adrenoreceptor	Human	Gi/Go	NM_000683	X	X
Adrenergic	ADRB1	β1-adrenoreceptor	Human	Gs	NM_000684	X	X
Adrenergic	ADRB2	β2-adrenoreceptor	Human	Gs	NM_000024	X	X		X
Adrenergic	ADRB3	β3-adrenoreceptor	Human	Gs	NM_000025		X
Adrenergic	ADRA1A	α1A-adrenoreceptor	Human	Gq	NM_000680			X
Adrenergic	ADRA1B	α1B-adrenoreceptor	Human	Gq	NM_000679	X		X
Adrenergic	ADRA2A	α2A-adrenoreceptor	Human	Gi/Go	NM_000681	X	X
Adrenergic	ADRA2B	α2B-adrenoreceptor	Human	Gi/Go	NM_000682.5	X
Anaphylatoxin	C3AR1	C3A	Human	Gi/Go	NM_004054.2	X	X		X
Anaphylatoxin	C5AR1	C5A	Human	Gi/Go	NM_001736	X	X		X
Anaphylatoxin	C5L2	C5L2	Human	None	NM_018485.1	X			X
Anaphylatoxin	mC5AR1	mC5AR	Mouse	Gi/Go	NM_007577.3	X
Angiotensin	AGTR1	AT1	Human	Gq	NM_000685	X		X
Apelin	AGTRL1	APJ	Human	Gi/Go	NM_005161	X	X		X
Apelin	mAGTRL1	mAPJ	Mouse	Gi/Go	NM_011784.2	X
Bile acid	GPBAR1	GPBA	Human	Gs	NM_001077194.1	X	X
Bombesin	BRS3	BB3	Human	Gq	NM_001727	X		X
Bombesin	GRPR	BB2	Human	Gq	NM_005314	X		X	X
Bradykinin	BDKRB1	B1	Human	Gq	NM_000710.2	X		X
Bradykinin	BDKRB2	B2	Human	Gq	NM_000623.3	X		X	X
Calcitonin	CALCR	CT	Human	Gs	NM_001742.2	X	X
Calcitonin	CALCR + RAMP1	AMY1	Human	Gs	NM_001742.2		X
Calcitonin	CALCR + RAMP2	AMY2	Human	Gs	NM_001742.2	X
Calcitonin	CALCR + RAMP3	AMY3	Human	Gs	NM_001742.2	X	X
Calcitonin	CALCRL + RAMP1	CGRP	Human	Gs	AY389506	X	X
Calcitonin	CALCRL + RAMP2	AM1	Human	Gs	AY389506	X	X
Calcitonin	CALCRL + RAMP3	AM2	Human	Gs	AY389506	X	X
Calcium sensing	CASR	CaS	Human	Gq & Gi/Go	NM_000388.3			X
Cannabinoid	CNR1	CB1	Human	Gi/Go	AY225225	X	X
Cannabinoid	CNR2	CB2	Human	Gi/Go	AY242132	X	X
Cannabinoid	mCNR1	mCB1	Mouse	Gi/Go	NM_007726	X
Cannabinoid	mCNR2	mCB2	Mouse	Gi/Go	NM_009924	X
Chemokine	CCR1	CCR1	Human	Gi/Go	NM_001295	X	X		X
Chemokine	CCR10	CCR10	Human	Gi/Go	AY429103	X	X		X
Chemokine	CCR2	CCR2	Human	Gi/Go	NM_001123396	X			X
Chemokine	CCR3	CCR3	Human	Gi/Go	NM_001837	X
Chemokine	CCR4	CCR4	Human	Gi/Go	AY322539	X			X
Chemokine	CCR5	CCR5	Human	Gi/Go	BC038398	X	X		X
Chemokine	CCR6	CCR6	Human	Gi/Go	AY242126	X	X		X
Chemokine	CCR7	CCR7	Human	Gi/Go	AY587876	X	X		X
Chemokine	CCR8	CCR8	Human	Gi/Go	NM_005201.3	X
Chemokine	CCR9	CCR9	Human	Gi/Go	AY242127	X
Chemokine	CMKLR1	CMKLR1	Human	Gi/Go	NM_004072.2	X	X
Chemokine	CX3CR1	CX3CR1	Human	Gi/Go	NM_001337	X
Chemokine	CXCR1	CXCR1	Human	Gi/Go	NM_000634	X	X		X
Chemokine	CXCR2	CXCR2	Human	Gi/Go	NM_001557	X	X		X
Chemokine	CXCR3	CXCR3	Human	Gi/Go	AY242128	X	X		X
Chemokine	CXCR4	CXCR4	Human	Gi/Go	AY242129	X	X
Chemokine	CXCR5	CXCR5	Human	Gi/Go	NM_001716	X	X
Chemokine	CXCR6	CXCR6	Human	Gi/Go	AY322543	X	X		X
Chemokine	CXCR7	CXCR7	Human	None	NM_020311.2	X			X
Chemokine	XCR1	XCR1	Human	Gi/Go	NM_005283	X	X
Chemokine	mCCR1	mCC1	Mouse	Gi/Go	NM_009912	X
Chemokine	mCCR10	mCCR10	Mouse	Gi/Go	AY429103	X
Chemokine	mCCR2	mCCR2	Mouse	Gi/Go	NM_009915.2	X
Chemokine	mCCR3	mCCR3	Mouse	Gi/Go	NM_009914	X
Chemokine	mCCR4	mCCR4	Mouse	Gi/Go	NM_006619	X
Chemokine	mCCR5	mCCR5	Mouse	Gi/Go	NM_009917	X
Chemokine	mCCR6	mCCR6	Mouse	Gi/Go	NM_009835.3	X
Chemokine	mCCR7	mCCR7	Mouse	Gi/Go	NM_007719.2	X
Chemokine	mCCR8	mCCR8	Mouse	Gi/Go	NM_007720.2	X
Chemokine	mCMKLR1	mCMKLR1	Mouse	Gi/Go	NM_008153.2	X
Chemokine	mCXCR2	mCXCR2	Mouse	Gi/Go	NM_009909	X
Chemokine	mCXCR3	mCXCR3	Mouse	Gi/Go	NM_009910	X
Chemokine	mCXCR4	mCXCR4	Mouse	Gi/Go	XM_001478244.1	X
Chemokine	mCXCR5	mCXCR5	Mouse	Gi/Go	NM_007551	X
Chemokine	mCXCR6	mCXCR6	Mouse	Gi/Go	NM_030712	X
Chemokine	mCXCR7	mCXCR7	Mouse	None	NM_007722	X
Chemokine	mCCR9	mCCR9	Mouse	Gi/Go	NM_007713.5	X
Cholecystokinin	CCKAR	CCK1	Human	Gq	AY322549	X		X	X
Cholecystokinin	CCKBR	CCK2	Human	Gq	AY322551	X		X	X
Class A Orphan	EBI2	GPR183	Human	Gi/Go	NM_080818	X
Class A Orphan	GPR1	GPR1	Human	N/A	NM_005279	X			X
Class A Orphan	GPR119	GPR119	Human	Unknown	NM_178471	X
Class A Orphan	GPR120	GPR120	Human	Unknown	NM_181745	X			X
Class A Orphan	GPR35	GPR35	Human	Gi/Go	NM_005301	X	X
Class A Orphan	GPR55	GPR55	Human	Unknown	NM_005683.3	X
Class A Orphan	GPR84	GPR84	Human	Gi/Go	NM_020370	X	X
Class A Orphan	GPR91	SUCNR1	Human	Unknown	NM_033050	X
Class A Orphan	GPR92	GPR92	Human	Gq	NM_020400	X		X
Class A Orphan	MRGPRX2	MRGX2	Human	Gq	NM_054030	X		X
Class A Orphan	CCRL2	CCRL2	Human	Unknown	NM_003965	X
Class A Orphan	GHSR1b	GHSR1b	Human	Unknown	NM_004122	X
Class A Orphan	GPR101	GPR101	Human	Unknown	NM_054021	X
Class A Orphan	GPR12	GPR12	Human	Unknown	NM_005288	X
Class A Orphan	GPR132	GPR132	Human	Unknown	NM_013345	X
Class A Orphan	GPR135	GPR135	Human	Unknown	NM_022571	X
Class A Orphan	GPR139	GPR139	Human	Unknown	NM_171791	X
Class A Orphan	GPR141	GPR141	Human	Unknown	NM_181791	X
Class A Orphan	GPR142	GPR142	Human	Unknown	NM_181790	X
Class A Orphan	GPR146	GPR146	Human	Unknown	NM_138445	X
Class A Orphan	GPR148	GPR148	Human	Unknown	XM_293092	X
Class A Orphan	GPR149	GPR149	Human	Unknown	XM_293580	X
Class A Orphan	GPR15	GPR15	Human	Unknown	NM_005290.1	X
Class A Orphan	GPR150	GPR150	Human	Unknown	XM_209675	X
Class A Orphan	GPR151	GPR151	Human	Unknown	NM_194251	X
Class A Orphan	GPR152	GPR152	Human	Unknown	XM_352045	X
Class A Orphan	GPR161	GPR161	Human	Unknown	NM_153832.1	X
Class A Orphan	GPR162	GPR162	Human	Unknown	NM_019858	X
Class A Orphan	GPR17	GPR17	Human	Unknown	NM_005291	X
Class A Orphan	GPR171	GPR171	Human	Unknown	NM_013308	X
Class A Orphan	GPR173	GPR173	Human	Unknown	NM_018969	X
Class A Orphan	GPR176	GPR176	Human	Unknown	NM_007223	X
Class A Orphan	GPR18	GPR18	Human	Unknown	NM_005292	X
Class A Orphan	GPR182	GPR182	Human	Unknown	NM_007264	X
Class A Orphan	GPR20	GPR20	Human	Unknown	NM_005293	X
Class A Orphan	GPR23	LPA4	Human	Unknown	NM_005296	X
Class A Orphan	GPR25	GPR25	Human	Unknown	NM_005298	X
Class A Orphan	GPR26	GPR26	Human	Unknown	NM_153442	X
Class A Orphan	GPR27	GPR27	Human	Unknown	NM_018971	X
Class A Orphan	GPR3	GPR3	Human	Unknown	NM_005281	X
Class A Orphan	GPR31	GPR31	Human	Unknown	NM_005299	X
Class A Orphan	GPR32	GPR32	Human	Unknown	NM_001506	X
Class A Orphan	GPR37	EDNRBL	Human	Unknown	NM_005302	X
Class A Orphan	GPR37L1	GPR37L1	Human	Unknown	NM_004767	X
Class A Orphan	GPR39	GPR39	Human	Gq	NM_001508	X
Class A Orphan	GPR4	GPR4	Human	Unknown	NM_005282	X
Class A Orphan	GPR45	GPR45	Human	Unknown	NM_007227	X
Class A Orphan	GPR50	GPR50	Human	Unknown	NM_004224	X
Class A Orphan	GPR52	GPR52	Human	Unknown	NM_005684	X
Class A Orphan	GPR6	GPR6	Human	Unknown	NM_005284	X
Class A Orphan	GPR61	GPR61	Human	Unknown	NM_031936	X
Class A Orphan	GPR65	GPR65	Human	Unknown	NM_003608	X
Class A Orphan	GPR75	GPR75	Human	Unknown	NM_006794	X
Class A Orphan	GPR78	GPR78	Human	Unknown	NM_080819	X
Class A Orphan	GPR79	GPR79	Human	Unknown	NM_001272	X
Class A Orphan	GPR83	GPR83	Human	Unknown	NM_016540	X
Class A Orphan	GPR85	GPR85	Human	Unknown	NM_018970	X
Class A Orphan	GPR88	GPR88	Human	Unknown	NM_022049	X
Class A Orphan	LGR4	LGR4	Human	Unknown	NM_018490	X
Class A Orphan	LGR5	LGR5	Human	Unknown	NM_003667	X
Class A Orphan	LGR6	LGR6	Human	Unknown	XM_097508	X
Class A Orphan	MRGPRD	MRGPRD	Human	Unknown	NM_198923	X
Class A Orphan	MRGPRE	MRGPRE	Human	Unknown	XM_171536	X
Class A Orphan	MRGPRF	MRGPRF	Human	Unknown	NM_145015	X
Class A Orphan	MRGPRX1	MRGPRX1	Human	Gq	NM_147199	X		X
Class A Orphan	MRGPRX4	MRGPRX4	Human	Unknown	NM_054032	X
Class A Orphan	OPN5	OPN5	Human	Unknown	NM_181744.2	X
Class A Orphan	OXGR1	OXGR1	Human	Gq	NM_080818.3	X
Class A Orphan	P2RY8	P2RY8	Human	Unknown	NM_178129	X
Class A Orphan	TAAR5	TAAR5	Human	Unknown	NM_003967.2	X
Class A Orphan	mGPR1	mGPR1	Mouse	Unknown	NM_146250	X
Class A Orphan	mGPR120	mGPR120	Mouse	Unknown	NM_181748	X
Class B Orphan	BAI1	BAI1	Human	unknown	NM_001702.2	X
Class B Orphan	BAI2	BAI2	Human	unknown	NM_001703.2	X
Class B Orphan	BAI3	BAI3	Human	unknown	NM_001704.2	X
Class B Orphan	GPR123	GPR123	Human	Unknown	NM_001083909	X
Class B Orphan	GPR157	GPR157	Human	Unknown	NM_024980	X
Class B Orphan	GPR97	GPR97	Human	Unknown	NM_170776	X
Corticotropin	CRHR1	CRF1	Human	Gs	AY457172	X	X		X
Corticotropin	CRHR2	CRF2	Human	Gs	AY449734	X	X
Corticotropin	mCRHR1	mCRF1	Mouse	Gs	NM_007762	X
Dopamine	DRD1	D1	Human	Gs	NM_000794.3	X	X
Dopamine	DRD2L	D2L	Human	Gi/Go	NM_000795.3	X	X
Dopamine	DRD2S	D2S	Human	Gi/Go	NM_016574.3	X	X
Dopamine	DRD3	D3	Human	Gi/Go	NM_000796.3	X
Dopamine	DRD4	D4	Human	Gi/Go	NM_000797.2	X	X
Dopamine	DRD5	D5	Human	Gs	NM_000798.3	X	X
Dopamine	mDRD5	mDRD5	Mouse	Gs	NM_013503.2	X
Dopamine	rDRD2L	rD2L	Rat	Gi/Go	NM_012547.1	X
Dopamine	rDRD2S	rD2S	Rat	Gi/Go	NM_016574.3	X
Dopamine	rDRD5	rD5	Rat	Gs	NM_000798.3	X
Endothelin	EDNRA	ETA	Human	Gq	AY275462	X		X
Endothelin	EDNRB	ETB	Human	Gs & Gi/Go	NM_000115.2	X			X
Endothelin	mEDNRA	mETA	Mouse	Gq	NM_010332.2	X
Endothelin	mEDNRB	mETB	Mouse	Gi/Go & Gs	NM_007904.3	X
Estrogen (G protein coupled) receptor	GPR30	GPER	Human	Gi/Go & Gs	NM_001505	X
Formylpeptide	FPR1	FPR1	Human	Gi/Go	NM_002029	X	X		X
Formylpeptide	FPRL1	FPR2/ALX	Human	Gi/Go	AY225226	X	X		X
Formylpeptide	mFPR1	mFPR1	Mouse	Gq	NM_013521.2	X
Free Fatty Acid	FFAR1	FFA1	Human	Gq	NM_005303.2	X		X
Free Fatty Acid	FFAR2	GPR43	Human	Gq & Gi/Go	NM_005306.2			X
Free Fatty Acid	FFAR3	GPR41	Human	Gi/Go	NM_005304.3		X
GABAB	GABBR1	GABB1	Human	N/A	NM_021903.2		X
Galanin	GALR1	GALR1	Human	Gi/Go	AY541036	X	X		X
Galanin	GALR2	GALR2	Human	Gq & Gs	NM_003857	X	X	X
Galanin	mGALR2	mGALR2	Mouse	Gi/Go	NM_010254.4	X
Ghrelin	GHSR1a	ghrelin	Human	Gq	NM_198407	X		X
Ghrelin	mGHSR1a	ghrelin	Mouse	Gq	NM_177330	X
Glucagon	GCGR	glucagon	Human	Gs	NM_000160	X	X		X
Glucagon	GHRHR	GHRH	Human	Gs	NM_000823.2		X
Glucagon	GIPR	GIP	Human	Gs	NM_000164	X	X		X
Glucagon	GLP1R	GLP-1	Human	Gs	BC112126	X	X		X
Glucagon	GLP2R	GLP-2	Human	Gs	NM004246.1	X	X		X
Glucagon	SCTR	secretin	Human	Gs	AY462218	X	X		X
Glucagon	mGCGR	glucagon	Mouse	Gs	NM_008101.2	X
Glucagon	mGIPR	mGIP	Mouse	Gs	NM_001080815.1	X
Glucagon	mGLP1R	mGLP-1	Mouse	Gs	NM_021332	X
Glutamate	GRM1	mGlu1	Human	Gq	NM_000838.2			X
Glutamate	GRM2	mGlu2	Human	Gi/Go	NM_000839		X
Glutamate	GRM3	MGlu3	Human	Gi/Go	NM_000840.2		X
Glutamate	GRM4	mGlu4	Human	Gi/Go	NM_000841		X
Glutamate	GRM6	mGlu6	Human	Gi/Go	NM_000843		X
Glycoprotein hormone receptor	FSHR	FSHR	Human	Gs	NM_000145	X	X
Glycoprotein hormone receptor	LHCGR	LH	Human	Gs	NM_000233	X	X
Glycoprotein hormone receptor	TSHR(L)	TSH	Human	Gs	NM_000369.2	X	X
Gonadotropin-releasing hormone	GNRHR	GnRH	Human	Gq	NM_000406.2			X
Histamine	HRH1	H1	Human	Gq	AY136743	X		X
Histamine	HRH2	H2	Human	Gs	AY136744	X	X
Histamine	HRH3	H3	Human	Gi/Go	NM_007232	X	X
Histamine	HRH4	H4	Human	Gi/Go	NM_021624	X
Hydroxycarboxylic acid	GPR109A	HCA2	Human	Gi/Go	NM_177551	X	X
Hydroxycarboxylic acid	GPR109B	HCA3	Human	Gi/Go	NM_006018	X	X
Hydroxycarboxylic acid	GPR81	HCA1	Human	Gi/Go	NM_032554	X	X
Kisspeptin receptor	KISS1R	kisspeptin	Human	Gq	NM_032551	X
Leukotriene	LTB4R	BLT1	Human	Gi/Go & Gq	AY322535	X	X	X	X
Leukotriene	OXER1	OXE	Human	Gi/Go	NM_148962.4		X
Leukotriene	CYSLTR2	CYSLT2	Human	Gq	NM_020377.2			X
Leukotriene	mLTB4R	mBLT1	Mouse	Gi/Go & Gq	NM_008519.2	X
Lysophospholipid	EDG1	S1P1	Human	Gi/Go	NM_001400	X	X		X
Lysophospholipid	EDG2	LPA1	Human	Gi/Go	NM_001401.3	X			X
Lysophospholipid	EDG3	S1P3	Human	Gq	NM_005226	X		X	X
Lysophospholipid	EDG4	LPA2	Human	Gq	AY322548	X		X
Lysophospholipid	EDG5	S1P2	Human	Gs	NM_004230.3	X			X
Lysophospholipid	EDG6	S1P4	Human	Gq	AY322537	X
Lysophospholipid	EDG7	LPA3	Human	Gq	NM_012152.2	X		X	X
Lysophospholipid	EDG8	S1P5	Human	Gi/Go	NM_030760.4	X
Lysophospholipid	cEDG5	cS1P2	Canine	Gs	XM_542076.2	X
Lysophospholipid	mEDG1	mS1P1	Mouse	Gi/Go	NM_007901	X
Lysophospholipid	mEDG5	mS1P2	Mouse	Gs	NM_010333.4	X
Lysophospholipid	mEDG6	mS1P4	Mouse	Gq	NM_010102.2	X
Lysophospholipid	rEDG5	rS1P2	Rat	Gs	NM_017192.2	X
Lysophospholipid	sEDG5	sS1P2	Simian	Gs	XM_001100481.1	X
Melanin-concentrating hormone	MCHR1	MCH1	Human	Gi/Go	AY562945	X	X
Melanin-concentrating hormone	MCHR2	MCH2	Human	Gq	NM_000706.3	X		X
Melanin-concentrating hormone	mMCHR1	MCH1	Mouse	Gi/Go	NM_145132	X
Melanocortin	MC1R	MC1	Human	Gs	NM_002386	X	X
Melanocortin	MC3R	MC3	Human	Gs	AY227893	X	X		X
Melanocortin	MC4R	MC4	Human	Gs	AY236539	X	X
Melanocortin	MC5R	MC5	Human	Gs	NM_005913	X	X
Melatonin	MTNR1A	MT1	Human	Gi/Go	NM_005958	X	X
Melatonin	MTNR1B	MT2	Human	Gi/Go	NM_005959.3	X	X
Motilin	MLNR	motilin	Human	Gq	AY603964	X		X	X
Neuromedin U	NMU1R	NMU1	Human	Gq	NM_006056	X		X	X
Neuropeptide B & W	NPBWR1	NPBW1	Human	Gi/Go	NM_005285	X	X
Neuropeptide B & W	NPBWR2	NPBW2	Human	Gi/Go	NM_005286	X	X
Neuropeptide F	NPFFR1	NPFF1	Human	Gi/Go	NM_022146	X	X
Neuropeptide F	NPFFR2	NPFF2	Human	Gi/Go	NM_053036.2		X
Neuropeptide S	NPSR1B	NPS receptor	Human	Gq	NM_207172	X
Neuropeptide Y	NPY1R	Y1	Human	Gi/Go	AY548168	X	X
Neuropeptide Y	NPY2R	Y2	Human	Gi/Go	AY236540	X	X	X	X
Neuropeptide Y	PPYR1	Y4	Human	Gi/Go	AY268432	X	X
Neuropeptide Y	mNPY1R	Y1	Mouse	Gi/Go	NM_010934.4	X
Neuropeptide Y	mNPY2R	NPY2R	Mouse	Gi/Go & Gq	NM_008731.3	X
Neuropeptide Y	mPPYR1	Y4	Mouse	Gi/Go	NM_008919.4	X
Neurotensin	NTSR1	NTS1	Human	Gq	AY429106	X		X	X
Non-signalling 7TM chemokine-binding proteins	DARC	FY	Human	Unknown	NM_002027	X
Opioid	OPRD1	δ	Human	Gi/Go	NM_000911	X	X		X
Opioid	OPRK1	κ	Human	Gi/Go	AF498922	X	X		X
Opioid	OPRL1	NOP	Human	Gi/Go	AY268428	X	X
Opioid	OPRM1	μ	Human	Gi/Go	NM_000914.3	X	X		X
Opioid	mOPRD1	δ (murine)	Mouse	Gi/Go	NM_013622.3	X
Opioid	mOPRK1	κ (murine)	Mouse	Gi/Go	NM_011011	X
Opioid	mOPRM1	μ (murine)	Mouse	Gi/Go	NM_001039652	X
Opioid	rOPRM1	μ	Rat	Gi/Go	NM_013071	X
Orexin	HCRTR1	OX1	Human	Gq	NM_001525.2	X		X	X
Orexin	HCRTR2	OX2	Human	Gq	AF041245	X		X	X
Orexin	mHCRTR1	mOX1	Mouse	Gq	AY062030	X
Other 7TM proteins	GPR107	GPR107	Human	Unknown	NM_020960	X
Other 7TM proteins	GPR137	TM7SF1	Human	Unknown	NM_003272	X
Other 7TM proteins	GPR143	GPR143	Human	Unknown	NM_000273	X
P2Y	P2RY1	P2RY1	Human	Gq	NM_002563.2	X		X
P2Y	P2RY11	P2Y11	Human	Gs & Gq	AY449733	X		X	X
P2Y	P2RY12	P2Y12	Human	Gi/Go	AY136754	X
P2Y	P2RY2	P2Y2	Human	Gq	AY136753	X		X	X
P2Y	P2RY4	P2Y4	Human	Gq	NM_002565	X		X	X
P2Y	P2RY6	P2Y6	Human	Gq	NM_004154	X
P2Y	mP2RY12	mP2Y12	Mouse	Gi/Go	NM_027571.3	X
P2Y	mP2RY6	P2Y6	Mouse	Gq	NM_183168.1	X
Parathyroid	PTHR1	PTH1	Human	Gs & Gq	AY449732	X	X	X	X
Parathyroid	PTHR2	PTH2	Human	Gs	AY497546	X	X	X	X
Peptide P518 receptor	GPR103	QRFPR	Human	Gq	NM_198179	X		X
Platelet-activating factor	PTAFR	PAF	Human	Gi/Go & Gq	AY275466	X	X	X	X
Platelet-activating factor	mPTAFR	mPAF	Mouse	Gi/Go & Gq	NM_001081211.1	X
Prokineticin	PROKR1	PKR1	Human	Gs & Gq	NM_138964	X	X	X	X
Prokineticin	PROKR2	PKR2	Human	Gs	NM_144773	X			X
Prokineticin	rPROKR1	rPROKR1	Rat	Gs & Gq		X
Prokineticin	rPROKR2	rPKR2	Rat	Gs	NM_138978	X
Prolactin releasing peptide receptor	PRLHR	PRRP	Human	Gq	NM_004248	X		X	X
Prostanoid	PTGER2	EP2	Human	Gs	AY275471	X
Prostanoid	PTGER3	EP3	Human	Gi/Go & Gq	NM_198716	X	X	X
Prostanoid	PTGER4	EP4	Human	Gs	AY429109	X			X
Prostanoid	PTGFR	FP	Human	Gq	NM_000959.3	X		X	X
Prostanoid	PTGIR	IP1	Human	Gs	AY242134	X	X		X
Prostanoid	TBXA2R	TP	Human	Gq	NM_001060	X		X
Prostanoid	CRTH2	DP2	Human	Gi/Go	AY507142	X	X
Prostanoid	PTGDR	DP1	Human	Gs	NM_000953		X
Prostanoid	PTGER1	EP1	Human	Gq	NM_000955.2	X		X
Prostanoid	mCRTH2	mDP2	Mouse	Gi/Go	NM_009962.2	X
Prostanoid	rCRTH2	rGPR44	Rat	Gi/Go	NM_001012070.1	X
Protease activated	F2R	PAR1	Human	Gi/Go	BC002464	X		X
Protease activated	F2RL1	PAR2	Human	Gi/Go & Gq	NM_005242.4	X		X	X
Protease activated	F2RL3	PAR4	Human	Gi/Go & Gq	AY431102	X		X	X
Relaxin	RXFP1	RXFP1	Human	Gs	NM_021634.2		X
Relaxin	RXFP3	RXFP3	Human	Gi/Go	NM_016568.2	X	X
Relaxin	RXFP4	RXFP4	Human	Gi/Go	NM_181885.2	X	X	X
Somatostatin	SSTR1	SST1	Human	Gi/Go	NM_001049	X
Somatostatin	SSTR2	SST2	Human	Gi/Go	AY236542	X	X		X
Somatostatin	SSTR3	SST3	Human	Gi/Go	AY322541	X	X
Somatostatin	SSTR4	SST4	Human	Gi/Go	AY548169	X	X
Somatostatin	SSTR5	SST5	Human	Gi/Go	NM_001053	X	X
Somatostatin	mSSTR2	mSST2	Mouse	Gi/Go	NM_001042606.1	X
Somatostatin	mSSTR5	mSRIF1B	Mouse	Gi/Go	NM_011425.2	X
Tachykinin	TACR1	NK1	Human	Gq	NM_001058	X		X	X
Tachykinin	TACR2	NK2	Human	Gq	AY322545	X		X	X
Tachykinin	TACR3	NK3	Human	Gs & Gq	NM_001059	X	X	X	X
TRH	TRHR	TRH1	Human	Gq	AY493373	X		X
Urotensin	UTR2	UT	Human	Gq	NM_018949	X		X	X
Urotensin	mUTR2	mUT	Mouse	Gq	NM_145440	X
Vasopressin and Oxytocin	AVPR1A	V1A	Human	Gq	NM_000706.3	X		X	X
Vasopressin and Oxytocin	AVPR1B	V1B	Human	Gq	NM_000707.3	X		X	X
Vasopressin and Oxytocin	AVPR2	V2	Human	Gs	NM_000054.4	X	X		X
Vasopressin and Oxytocin	OXTR	OT	Human	Gq	AY389507	X		X	X
Vasopressin and Oxytocin	mOXTR1	mOT	Mouse	Gq	NM_001081147.1	X
VIP and PACAP	ADCYAP1R1	PAC1	Human	Gs & Gq	AY366498	X	X	X	X
VIP and PACAP	VIPR1	VPAC1	Human	Gs & Gq	NM_004624	X	X		X
VIP and PACAP	VIPR2	VPAC2	Human	Gs	NM_003382	X	X		X
VIP and PACAP	mADCYAP1R1	mPAC1	Mouse	Gs & Gq	NM_001025372.1	X
VIP and PACAP	mVIPR1	mVPAC1	Mouse	Gs	NM_011703.4	X

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