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GPCR Targets Available

Industry-leading portfolio, multiple signaling pathways, innovative solutions

The foundation of the DiscoveRx outsourced solutions portfolio is our comprehensive collection of highly validated, robust GPCR assays using multiple readout platforms. Access to the same GPCR target in different technology formats allows multiple signaling pathways to be assayed in parallel which affords a unique opportunity to identify drug interactions that may be missed with a single signaling platform.

Overview of Available Readouts

Arrestin
Second messenger (cAMP & Calcium)
Internalization

GPCR Signaling Pathway

			Second Messenger
Assay Type	Arrestin	Internalization	cAMP	Calcium
Known
Orphan
Orthologs

Browse Available GPCR Targets

Listed below are the assays currently available for screening and profiling. Assays may be sorted by column name. Contact us if you don't see your target of interest in the list below as additional catalog assays may be available for screening and profiling as a custom service.

Family	Target Class	Common Name	Species	G protein coupling	Accession Number	Arrestin	cAMP	Calcium	Internalization
5-Hydroxytryptamine	GPCR	m5HT2A	Mouse	Gi/Go	NM_172812	X
5-Hydroxytryptamine	GPCR	m5HT2C	Mouse	Gi/Go	AF498983	X
5-Hydroxytryptamine	GPCR	5HT1A	Human	Gi/Go	NM_000524.2	X	X
5-Hydroxytryptamine	GPCR	5HT1B	Human	Gi/Go	NM_000863	X	X
5-Hydroxytryptamine	GPCR	5HT1E	Human	Gi/Go	NM_000865	X
5-Hydroxytryptamine	GPCR	5HT1F	Human	Gi/Go	NM_000866.3	X	X
5-Hydroxytryptamine	GPCR	5HT2A	Human	Gq	NM_000621.3	X		X	X
5-Hydroxytryptamine	GPCR	5HT2B	Human	Gq	NM_000867.4			X
5-Hydroxytryptamine	GPCR	5HT2C	Human	Gq	AF498983	X		X	X
5-Hydroxytryptamine	GPCR	5HT5A	Human	Gi/Go	NM_024012	X	X
5-Hydroxytryptamine	GPCR	5HT7A	Human	Gs	NM_000872.4		X
5-Hydroxytryptamine	GPCR	5HT7B	Human	Gs	NM_019860.3		X
5-Hydroxytryptamine	GPCR	5HT7D	Human	Gs	NM_000872		X
Acetylcholine	GPCR	rM4	Rat	Gs & Gi/Go	NM_000741	X
Acetylcholine	GPCR	M1	Human	Gq	AF498915	X		X	X
Acetylcholine	GPCR	M2	Human	Gi/Go	AF498916	X	X		X
Acetylcholine	GPCR	M3	Human	Gq	AF498917	X		X	X
Acetylcholine	GPCR	M4	Human	Gs & Gi/Go	NM_000741.2	X	X
Acetylcholine	GPCR	M5	Human	Gq	AF498919	X		X	X
Adenosine	GPCR	mA2B	Mouse	Gs	NM_007413	X
Adenosine	GPCR	mA3	Mouse	Gi/Go	NM_009631.3	X
Adenosine	GPCR	A1	Human	Gi/Go	AY136746	X	X	X
Adenosine	GPCR	A2A	Human	Gs & Gq	NM_000675.4			X
Adenosine	GPCR	A2B	Human	Gs	AY136748	X	X
Adenosine	GPCR	A3	Human	Gi/Go	NM_000677.3	X	X
Adrenergic	GPCR	α2C-adrenoreceptor	Human	Gi/Go	NM_000683	X	X
Adrenergic	GPCR	β1-adrenoreceptor	Human	Gs	NM_000684	X	X
Adrenergic	GPCR	β2-adrenoreceptor	Human	Gs	NM_000024	X	X		X
Adrenergic	GPCR	β3-adrenoreceptor	Human	Gs	NM_000025		X
Adrenergic	GPCR	α1A-adrenoreceptor	Human	Gq	NM_000680			X
Adrenergic	GPCR	α1B-adrenoreceptor	Human	Gq	NM_000679	X		X
Adrenergic	GPCR	α2A-adrenoreceptor	Human	Gi/Go	NM_000681	X	X
Adrenergic	GPCR	α2B-adrenoreceptor	Human	Gi/Go	NM_000682.5	X
Anaphylatoxin	GPCR	C3A	Human	Gi/Go	NM_004054.2	X	X		X
Anaphylatoxin	GPCR	C5A	Human	Gi/Go	NM_001736	X	X		X
Anaphylatoxin	GPCR	C5L2	Human	None	NM_018485.1	X			X
Anaphylatoxin	GPCR	mC5AR	Mouse	Gi/Go	NM_007577.3	X
Angiotensin	GPCR	AT1	Human	Gq	NM_000685	X		X
Apelin	GPCR	APJ	Human	Gi/Go	NM_005161	X	X		X
Apelin	GPCR	mAPJ	Mouse	Gi/Go	NM_011784.2	X
Bile acid	GPCR	GPBA	Human	Gs	NM_001077194.1	X	X
Bombesin	GPCR	BB3	Human	Gq	NM_001727	X		X
Bombesin	GPCR	BB2	Human	Gq	NM_005314	X		X	X
Bradykinin	GPCR	B1	Human	Gq	NM_000710.2	X		X
Bradykinin	GPCR	B2	Human	Gq	NM_000623.3	X		X	X
Calcitonin	GPCR	CT	Human	Gs	NM_001742.2	X	X
Calcitonin	GPCR	AMY1	Human	Gs	NM_001742.2		X
Calcitonin	GPCR	AMY2	Human	Gs	NM_001742.2	X
Calcitonin	GPCR	AMY3	Human	Gs	NM_001742.2	X	X
Calcitonin	GPCR	CGRP	Human	Gs	AY389506	X	X
Calcitonin	GPCR	AM1	Human	Gs	AY389506	X	X
Calcitonin	GPCR	AM2	Human	Gs	AY389506	X	X
Calcium sensing	GPCR	CaS	Human	Gq & Gi/Go	NM_000388.3			X
Cannabinoid	GPCR	CB1	Human	Gi/Go	AY225225	X	X
Cannabinoid	GPCR	CB2	Human	Gi/Go	AY242132	X	X
Cannabinoid	GPCR	mCB1	Mouse	Gi/Go	NM_007726	X
Cannabinoid	GPCR	mCB2	Mouse	Gi/Go	NM_009924	X
Chemokine	GPCR	CCR1	Human	Gi/Go	NM_001295	X	X		X
Chemokine	GPCR	CCR10	Human	Gi/Go	AY429103	X	X		X
Chemokine	GPCR	CCR2	Human	Gi/Go	NM_001123396	X			X
Chemokine	GPCR	CCR3	Human	Gi/Go	NM_001837	X
Chemokine	GPCR	CCR4	Human	Gi/Go	AY322539	X			X
Chemokine	GPCR	CCR5	Human	Gi/Go	BC038398	X	X		X
Chemokine	GPCR	CCR6	Human	Gi/Go	AY242126	X	X		X
Chemokine	GPCR	CCR7	Human	Gi/Go	AY587876	X	X		X
Chemokine	GPCR	CCR8	Human	Gi/Go	NM_005201.3	X
Chemokine	GPCR	CCR9	Human	Gi/Go	AY242127	X
Chemokine	GPCR	CMKLR1	Human	Gi/Go	NM_004072.2	X	X
Chemokine	GPCR	CX3CR1	Human	Gi/Go	NM_001337	X
Chemokine	GPCR	CXCR1	Human	Gi/Go	NM_000634	X	X		X
Chemokine	GPCR	CXCR2	Human	Gi/Go	NM_001557	X	X		X
Chemokine	GPCR	CXCR3	Human	Gi/Go	AY242128	X	X		X
Chemokine	GPCR	CXCR4	Human	Gi/Go	AY242129	X	X
Chemokine	GPCR	CXCR5	Human	Gi/Go	NM_001716	X	X
Chemokine	GPCR	CXCR6	Human	Gi/Go	AY322543	X	X		X
Chemokine	GPCR	CXCR7	Human	None	NM_020311.2	X			X
Chemokine	GPCR	XCR1	Human	Gi/Go	NM_005283	X	X
Chemokine	GPCR	mCC1	Mouse	Gi/Go	NM_009912	X
Chemokine	GPCR	mCCR10	Mouse	Gi/Go	AY429103	X
Chemokine	GPCR	mCCR2	Mouse	Gi/Go	NM_009915.2	X
Chemokine	GPCR	mCCR3	Mouse	Gi/Go	NM_009914	X
Chemokine	GPCR	mCCR4	Mouse	Gi/Go	NM_006619	X
Chemokine	GPCR	mCCR5	Mouse	Gi/Go	NM_009917	X
Chemokine	GPCR	mCCR6	Mouse	Gi/Go	NM_009835.3	X
Chemokine	GPCR	mCCR7	Mouse	Gi/Go	NM_007719.2	X
Chemokine	GPCR	mCCR8	Mouse	Gi/Go	NM_007720.2	X
Chemokine	GPCR	mCMKLR1	Mouse	Gi/Go	NM_008153.2	X
Chemokine	GPCR	mCXCR2	Mouse	Gi/Go	NM_009909	X
Chemokine	GPCR	mCXCR3	Mouse	Gi/Go	NM_009910	X
Chemokine	GPCR	mCXCR4	Mouse	Gi/Go	XM_001478244.1	X
Chemokine	GPCR	mCXCR5	Mouse	Gi/Go	NM_007551	X
Chemokine	GPCR	mCXCR6	Mouse	Gi/Go	NM_030712	X
Chemokine	GPCR	mCXCR7	Mouse	None	NM_007722	X
Chemokine	GPCR	mCCR9	Mouse	Gi/Go	NM_007713.5	X
Cholecystokinin	GPCR	CCK1	Human	Gq	AY322549	X		X	X
Cholecystokinin	GPCR	CCK2	Human	Gq	AY322551	X		X	X
Class A Orphan	GPCR	GPR183	Human	Gi/Go	NM_080818	X
Class A Orphan	GPCR	GPR1	Human	N/A	NM_005279	X			X
Class A Orphan	GPCR	GPR119	Human	Unknown	NM_178471	X
Class A Orphan	GPCR	GPR120	Human	Unknown	NM_181745	X			X
Class A Orphan	GPCR	GPR35	Human	Gi/Go	NM_005301	X	X
Class A Orphan	GPCR	GPR55	Human	Unknown	NM_005683.3	X
Class A Orphan	GPCR	GPR84	Human	Gi/Go	NM_020370	X	X
Class A Orphan	GPCR	SUCNR1	Human	Unknown	NM_033050	X
Class A Orphan	GPCR	GPR92	Human	Gq	NM_020400	X		X
Class A Orphan	GPCR	MRGX2	Human	Gq	NM_054030	X		X
Class A Orphan	GPCR	CCRL2	Human	Unknown	NM_003965	X
Class A Orphan	GPCR	GHSR1b	Human	Unknown	NM_004122	X
Class A Orphan	GPCR	GPR101	Human	Unknown	NM_054021	X
Class A Orphan	GPCR	GPR12	Human	Unknown	NM_005288	X
Class A Orphan	GPCR	GPR132	Human	Unknown	NM_013345	X
Class A Orphan	GPCR	GPR135	Human	Unknown	NM_022571	X
Class A Orphan	GPCR	GPR139	Human	Unknown	NM_171791	X
Class A Orphan	GPCR	GPR141	Human	Unknown	NM_181791	X
Class A Orphan	GPCR	GPR142	Human	Unknown	NM_181790	X
Class A Orphan	GPCR	GPR146	Human	Unknown	NM_138445	X
Class A Orphan	GPCR	GPR148	Human	Unknown	XM_293092	X
Class A Orphan	GPCR	GPR149	Human	Unknown	XM_293580	X
Class A Orphan	GPCR	GPR15	Human	Unknown	NM_005290.1	X
Class A Orphan	GPCR	GPR150	Human	Unknown	XM_209675	X
Class A Orphan	GPCR	GPR151	Human	Unknown	NM_194251	X
Class A Orphan	GPCR	GPR152	Human	Unknown	XM_352045	X
Class A Orphan	GPCR	GPR161	Human	Unknown	NM_153832.1	X
Class A Orphan	GPCR	GPR162	Human	Unknown	NM_019858	X
Class A Orphan	GPCR	GPR17	Human	Unknown	NM_005291	X
Class A Orphan	GPCR	GPR171	Human	Unknown	NM_013308	X
Class A Orphan	GPCR	GPR173	Human	Unknown	NM_018969	X
Class A Orphan	GPCR	GPR176	Human	Unknown	NM_007223	X
Class A Orphan	GPCR	GPR18	Human	Unknown	NM_005292	X
Class A Orphan	GPCR	GPR182	Human	Unknown	NM_007264	X
Class A Orphan	GPCR	GPR20	Human	Unknown	NM_005293	X
Class A Orphan	GPCR	LPA4	Human	Unknown	NM_005296	X
Class A Orphan	GPCR	GPR25	Human	Unknown	NM_005298	X
Class A Orphan	GPCR	GPR26	Human	Unknown	NM_153442	X
Class A Orphan	GPCR	GPR27	Human	Unknown	NM_018971	X
Class A Orphan	GPCR	GPR3	Human	Unknown	NM_005281	X
Class A Orphan	GPCR	GPR31	Human	Unknown	NM_005299	X
Class A Orphan	GPCR	GPR32	Human	Unknown	NM_001506	X
Class A Orphan	GPCR	EDNRBL	Human	Unknown	NM_005302	X
Class A Orphan	GPCR	GPR37L1	Human	Unknown	NM_004767	X
Class A Orphan	GPCR	GPR39	Human	Gq	NM_001508	X
Class A Orphan	GPCR	GPR4	Human	Unknown	NM_005282	X
Class A Orphan	GPCR	GPR45	Human	Unknown	NM_007227	X
Class A Orphan	GPCR	GPR50	Human	Unknown	NM_004224	X
Class A Orphan	GPCR	GPR52	Human	Unknown	NM_005684	X
Class A Orphan	GPCR	GPR6	Human	Unknown	NM_005284	X
Class A Orphan	GPCR	GPR61	Human	Unknown	NM_031936	X
Class A Orphan	GPCR	GPR65	Human	Unknown	NM_003608	X
Class A Orphan	GPCR	GPR75	Human	Unknown	NM_006794	X
Class A Orphan	GPCR	GPR78	Human	Unknown	NM_080819	X
Class A Orphan	GPCR	GPR79	Human	Unknown	NM_001272	X
Class A Orphan	GPCR	GPR83	Human	Unknown	NM_016540	X
Class A Orphan	GPCR	GPR85	Human	Unknown	NM_018970	X
Class A Orphan	GPCR	GPR88	Human	Unknown	NM_022049	X
Class A Orphan	GPCR	LGR4	Human	Unknown	NM_018490	X
Class A Orphan	GPCR	LGR5	Human	Unknown	NM_003667	X
Class A Orphan	GPCR	LGR6	Human	Unknown	XM_097508	X
Class A Orphan	GPCR	MRGPRD	Human	Unknown	NM_198923	X
Class A Orphan	GPCR	MRGPRE	Human	Unknown	XM_171536	X
Class A Orphan	GPCR	MRGPRF	Human	Unknown	NM_145015	X
Class A Orphan	GPCR	MRGPRX1	Human	Gq	NM_147199	X		X
Class A Orphan	GPCR	MRGPRX4	Human	Unknown	NM_054032	X
Class A Orphan	GPCR	OPN5	Human	Unknown	NM_181744.2	X
Class A Orphan	GPCR	OXGR1	Human	Gq	NM_080818.3	X
Class A Orphan	GPCR	P2RY8	Human	Unknown	NM_178129	X
Class A Orphan	GPCR	TAAR5	Human	Unknown	NM_003967.2	X
Class A Orphan	GPCR	mGPR1	Mouse	Unknown	NM_146250	X
Class A Orphan	GPCR	mGPR120	Mouse	Unknown	NM_181748	X
Class B Orphan	GPCR	BAI1	Human	unknown	NM_001702.2	X
Class B Orphan	GPCR	BAI2	Human	unknown	NM_001703.2	X
Class B Orphan	GPCR	BAI3	Human	unknown	NM_001704.2	X
Class B Orphan	GPCR	GPR123	Human	Unknown	NM_001083909	X
Class B Orphan	GPCR	GPR157	Human	Unknown	NM_024980	X
Class B Orphan	GPCR	GPR97	Human	Unknown	NM_170776	X
Corticotropin	GPCR	CRF1	Human	Gs	AY457172	X	X		X
Corticotropin	GPCR	CRF2	Human	Gs	AY449734	X	X
Corticotropin	GPCR	mCRF1	Mouse	Gs	NM_007762	X
Dopamine	GPCR	D1	Human	Gs	NM_000794.3	X	X
Dopamine	GPCR	D2L	Human	Gi/Go	NM_000795.3	X	X
Dopamine	GPCR	D2S	Human	Gi/Go	NM_016574.3	X	X
Dopamine	GPCR	D3	Human	Gi/Go	NM_000796.3	X
Dopamine	GPCR	D4	Human	Gi/Go	NM_000797.2	X	X
Dopamine	GPCR	D5	Human	Gs	NM_000798.3	X	X
Dopamine	GPCR	mDRD5	Mouse	Gs	NM_013503.2	X
Dopamine	GPCR	rD2L	Rat	Gi/Go	NM_012547.1	X
Dopamine	GPCR	rD2S	Rat	Gi/Go	NM_016574.3	X
Dopamine	GPCR	rD5	Rat	Gs	NM_000798.3	X
Endothelin	GPCR	ETA	Human	Gq	AY275462	X		X
Endothelin	GPCR	ETB	Human	Gs & Gi/Go	NM_000115.2	X			X
Endothelin	GPCR	mETA	Mouse	Gq	NM_010332.2	X
Endothelin	GPCR	mETB	Mouse	Gi/Go & Gs	NM_007904.3	X
Estrogen (G protein coupled) receptor	GPCR	GPER	Human	Gi/Go & Gs	NM_001505	X
Formylpeptide	GPCR	FPR1	Human	Gi/Go	NM_002029	X	X		X
Formylpeptide	GPCR	FPR2/ALX	Human	Gi/Go	AY225226	X	X		X
Formylpeptide	GPCR	mFPR1	Mouse	Gq	NM_013521.2	X
Free Fatty Acid	GPCR	FFA1	Human	Gq	NM_005303.2	X		X
Free Fatty Acid	GPCR	GPR43	Human	Gq & Gi/Go	NM_005306.2			X
Free Fatty Acid	GPCR	GPR41	Human	Gi/Go	NM_005304.3		X
GABAB	GPCR	GABB1	Human	N/A	NM_021903.2		X
Galanin	GPCR	GALR1	Human	Gi/Go	AY541036	X	X		X
Galanin	GPCR	GALR2	Human	Gq & Gs	NM_003857	X	X	X
Galanin	GPCR	mGALR2	Mouse	Gi/Go	NM_010254.4	X
Ghrelin	GPCR	ghrelin	Human	Gq	NM_198407	X		X
Ghrelin	GPCR	ghrelin	Mouse	Gq	NM_177330	X
Glucagon	GPCR	glucagon	Human	Gs	NM_000160	X	X		X
Glucagon	GPCR	GHRH	Human	Gs	NM_000823.2		X
Glucagon	GPCR	GIP	Human	Gs	NM_000164	X	X		X
Glucagon	GPCR	GLP-1	Human	Gs	BC112126	X	X		X
Glucagon	GPCR	GLP-2	Human	Gs	NM004246.1	X	X		X
Glucagon	GPCR	secretin	Human	Gs	AY462218	X	X		X
Glucagon	GPCR	glucagon	Mouse	Gs	NM_008101.2	X
Glucagon	GPCR	mGIP	Mouse	Gs	NM_001080815.1	X
Glucagon	GPCR	mGLP-1	Mouse	Gs	NM_021332	X
Glutamate	GPCR	mGlu1	Human	Gq	NM_000838.2			X
Glutamate	GPCR	mGlu2	Human	Gi/Go	NM_000839		X
Glutamate	GPCR	MGlu3	Human	Gi/Go	NM_000840.2		X
Glutamate	GPCR	mGlu4	Human	Gi/Go	NM_000841		X
Glutamate	GPCR	mGlu6	Human	Gi/Go	NM_000843		X
Glycoprotein hormone receptor	GPCR	FSHR	Human	Gs	NM_000145	X	X
Glycoprotein hormone receptor	GPCR	LH	Human	Gs	NM_000233	X	X
Glycoprotein hormone receptor	GPCR	TSH	Human	Gs	NM_000369.2	X	X
Gonadotropin-releasing hormone	GPCR	GnRH	Human	Gq	NM_000406.2			X
Histamine	GPCR	H1	Human	Gq	AY136743	X		X
Histamine	GPCR	H2	Human	Gs	AY136744	X	X
Histamine	GPCR	H3	Human	Gi/Go	NM_007232	X	X
Histamine	GPCR	H4	Human	Gi/Go	NM_021624	X
Hydroxycarboxylic acid	GPCR	HCA2	Human	Gi/Go	NM_177551	X	X
Hydroxycarboxylic acid	GPCR	HCA3	Human	Gi/Go	NM_006018	X	X
Hydroxycarboxylic acid	GPCR	HCA1	Human	Gi/Go	NM_032554	X	X
Kisspeptin receptor	GPCR	kisspeptin	Human	Gq	NM_032551	X
Leukotriene	GPCR	BLT1	Human	Gi/Go & Gq	AY322535	X	X	X	X
Leukotriene	GPCR	OXE	Human	Gi/Go	NM_148962.4		X
Leukotriene	GPCR	CYSLT2	Human	Gq	NM_020377.2			X
Leukotriene	GPCR	mBLT1	Mouse	Gi/Go & Gq	NM_008519.2	X
Lysophospholipid	GPCR	S1P1	Human	Gi/Go	NM_001400	X	X		X
Lysophospholipid	GPCR	LPA1	Human	Gi/Go	NM_001401.3	X			X
Lysophospholipid	GPCR	S1P3	Human	Gq	NM_005226	X		X	X
Lysophospholipid	GPCR	LPA2	Human	Gq	AY322548	X		X
Lysophospholipid	GPCR	S1P2	Human	Gs	NM_004230.3	X			X
Lysophospholipid	GPCR	S1P4	Human	Gq	AY322537	X
Lysophospholipid	GPCR	LPA3	Human	Gq	NM_012152.2	X		X	X
Lysophospholipid	GPCR	S1P5	Human	Gi/Go	NM_030760.4	X
Lysophospholipid	GPCR	cS1P2	Canine	Gs	XM_542076.2	X
Lysophospholipid	GPCR	mS1P1	Mouse	Gi/Go	NM_007901	X
Lysophospholipid	GPCR	mS1P2	Mouse	Gs	NM_010333.4	X
Lysophospholipid	GPCR	mS1P4	Mouse	Gq	NM_010102.2	X
Lysophospholipid	GPCR	rS1P2	Rat	Gs	NM_017192.2	X
Lysophospholipid	GPCR	sS1P2	Simian	Gs	XM_001100481.1	X
Melanin-concentrating hormone	GPCR	MCH1	Human	Gi/Go	AY562945	X	X
Melanin-concentrating hormone	GPCR	MCH2	Human	Gq	NM_000706.3	X		X
Melanin-concentrating hormone	GPCR	MCH1	Mouse	Gi/Go	NM_145132	X
Melanocortin	GPCR	MC1	Human	Gs	NM_002386	X	X
Melanocortin	GPCR	MC3	Human	Gs	AY227893	X	X		X
Melanocortin	GPCR	MC4	Human	Gs	AY236539	X	X
Melanocortin	GPCR	MC5	Human	Gs	NM_005913	X	X
Melatonin	GPCR	MT1	Human	Gi/Go	NM_005958	X	X
Melatonin	GPCR	MT2	Human	Gi/Go	NM_005959.3	X	X
Motilin	GPCR	motilin	Human	Gq	AY603964	X		X	X
Neuromedin U	GPCR	NMU1	Human	Gq	NM_006056	X		X	X
Neuropeptide B & W	GPCR	NPBW1	Human	Gi/Go	NM_005285	X	X
Neuropeptide B & W	GPCR	NPBW2	Human	Gi/Go	NM_005286	X	X
Neuropeptide F	GPCR	NPFF1	Human	Gi/Go	NM_022146	X	X
Neuropeptide F	GPCR	NPFF2	Human	Gi/Go	NM_053036.2		X
Neuropeptide S	GPCR	NPS receptor	Human	Gq	NM_207172	X
Neuropeptide Y	GPCR	Y1	Human	Gi/Go	AY548168	X	X
Neuropeptide Y	GPCR	Y2	Human	Gi/Go	AY236540	X	X	X	X
Neuropeptide Y	GPCR	Y4	Human	Gi/Go	AY268432	X	X
Neuropeptide Y	GPCR	Y1	Mouse	Gi/Go	NM_010934.4	X
Neuropeptide Y	GPCR	NPY2R	Mouse	Gi/Go & Gq	NM_008731.3	X
Neuropeptide Y	GPCR	Y4	Mouse	Gi/Go	NM_008919.4	X
Neurotensin	GPCR	NTS1	Human	Gq	AY429106	X		X	X
Non-signalling 7TM chemokine-binding proteins	GPCR	FY	Human	Unknown	NM_002027	X
Opioid	GPCR	δ	Human	Gi/Go	NM_000911	X	X		X
Opioid	GPCR	κ	Human	Gi/Go	AF498922	X	X		X
Opioid	GPCR	NOP	Human	Gi/Go	AY268428	X	X
Opioid	GPCR	μ	Human	Gi/Go	NM_000914.3	X	X		X
Opioid	GPCR	δ (murine)	Mouse	Gi/Go	NM_013622.3	X
Opioid	GPCR	κ (murine)	Mouse	Gi/Go	NM_011011	X
Opioid	GPCR	μ (murine)	Mouse	Gi/Go	NM_001039652	X
Opioid	GPCR	μ	Rat	Gi/Go	NM_013071	X
Orexin	GPCR	OX1	Human	Gq	NM_001525.2	X		X	X
Orexin	GPCR	OX2	Human	Gq	AF041245	X		X	X
Orexin	GPCR	mOX1	Mouse	Gq	AY062030	X
Other 7TM proteins	GPCR	GPR107	Human	Unknown	NM_020960	X
Other 7TM proteins	GPCR	TM7SF1	Human	Unknown	NM_003272	X
Other 7TM proteins	GPCR	GPR143	Human	Unknown	NM_000273	X
P2Y	GPCR	P2RY1	Human	Gq	NM_002563.2	X		X
P2Y	GPCR	P2Y11	Human	Gs & Gq	AY449733	X		X	X
P2Y	GPCR	P2Y12	Human	Gi/Go	AY136754	X
P2Y	GPCR	P2Y2	Human	Gq	AY136753	X		X	X
P2Y	GPCR	P2Y4	Human	Gq	NM_002565	X		X	X
P2Y	GPCR	P2Y6	Human	Gq	NM_004154	X
P2Y	GPCR	mP2Y12	Mouse	Gi/Go	NM_027571.3	X
P2Y	GPCR	P2Y6	Mouse	Gq	NM_183168.1	X
Parathyroid	GPCR	PTH1	Human	Gs & Gq	AY449732	X	X	X	X
Parathyroid	GPCR	PTH2	Human	Gs	AY497546	X	X	X	X
Peptide P518 receptor	GPCR	QRFPR	Human	Gq	NM_198179	X		X
Platelet-activating factor	GPCR	PAF	Human	Gi/Go & Gq	AY275466	X	X	X	X
Platelet-activating factor	GPCR	mPAF	Mouse	Gi/Go & Gq	NM_001081211.1	X
Prokineticin	GPCR	PKR1	Human	Gs & Gq	NM_138964	X	X	X	X
Prokineticin	GPCR	PKR2	Human	Gs	NM_144773	X			X
Prokineticin	GPCR	rPROKR1	Rat	Gs & Gq		X
Prokineticin	GPCR	rPKR2	Rat	Gs	NM_138978	X
Prolactin releasing peptide receptor	GPCR	PRRP	Human	Gq	NM_004248	X		X	X
Prostanoid	GPCR	EP2	Human	Gs	AY275471	X
Prostanoid	GPCR	EP3	Human	Gi/Go & Gq	NM_198716	X	X	X
Prostanoid	GPCR	EP4	Human	Gs	AY429109	X			X
Prostanoid	GPCR	FP	Human	Gq	NM_000959.3	X		X	X
Prostanoid	GPCR	IP1	Human	Gs	AY242134	X	X		X
Prostanoid	GPCR	TP	Human	Gq	NM_001060	X		X
Prostanoid	GPCR	DP2	Human	Gi/Go	AY507142	X	X
Prostanoid	GPCR	DP1	Human	Gs	NM_000953		X
Prostanoid	GPCR	EP1	Human	Gq	NM_000955.2	X		X
Prostanoid	GPCR	mDP2	Mouse	Gi/Go	NM_009962.2	X
Prostanoid	GPCR	rGPR44	Rat	Gi/Go	NM_001012070.1	X
Protease activated	GPCR	PAR1	Human	Gi/Go	BC002464	X		X
Protease activated	GPCR	PAR2	Human	Gi/Go & Gq	NM_005242.4	X		X	X
Protease activated	GPCR	PAR4	Human	Gi/Go & Gq	AY431102	X		X	X
Relaxin	GPCR	RXFP1	Human	Gs	NM_021634.2		X
Relaxin	GPCR	RXFP3	Human	Gi/Go	NM_016568.2	X	X
Relaxin	GPCR	RXFP4	Human	Gi/Go	NM_181885.2	X	X	X
Somatostatin	GPCR	SST1	Human	Gi/Go	NM_001049	X
Somatostatin	GPCR	SST2	Human	Gi/Go	AY236542	X	X		X
Somatostatin	GPCR	SST3	Human	Gi/Go	AY322541	X	X
Somatostatin	GPCR	SST4	Human	Gi/Go	AY548169	X	X
Somatostatin	GPCR	SST5	Human	Gi/Go	NM_001053	X	X
Somatostatin	GPCR	mSST2	Mouse	Gi/Go	NM_001042606.1	X
Somatostatin	GPCR	mSRIF1B	Mouse	Gi/Go	NM_011425.2	X
Tachykinin	GPCR	NK1	Human	Gq	NM_001058	X		X	X
Tachykinin	GPCR	NK2	Human	Gq	AY322545	X		X	X
Tachykinin	GPCR	NK3	Human	Gs & Gq	NM_001059	X	X	X	X
TRH	GPCR	TRH1	Human	Gq	AY493373	X		X
Urotensin	GPCR	UT	Human	Gq	NM_018949	X		X	X
Urotensin	GPCR	mUT	Mouse	Gq	NM_145440	X
Vasopressin and Oxytocin	GPCR	V1A	Human	Gq	NM_000706.3	X		X	X
Vasopressin and Oxytocin	GPCR	V1B	Human	Gq	NM_000707.3	X		X	X
Vasopressin and Oxytocin	GPCR	V2	Human	Gs	NM_000054.4	X	X		X
Vasopressin and Oxytocin	GPCR	OT	Human	Gq	AY389507	X		X	X
Vasopressin and Oxytocin	GPCR	mOT	Mouse	Gq	NM_001081147.1	X
VIP and PACAP	GPCR	PAC1	Human	Gs & Gq	AY366498	X	X	X	X
VIP and PACAP	GPCR	VPAC1	Human	Gs & Gq	NM_004624	X	X		X
VIP and PACAP	GPCR	VPAC2	Human	Gs	NM_003382	X	X		X
VIP and PACAP	GPCR	mPAC1	Mouse	Gs & Gq	NM_001025372.1	X
VIP and PACAP	GPCR	mVPAC1	Mouse	Gs	NM_011703.4	X