Available Target Classes
Target classes available through DiscoveRx LeadHunter Discovery Services
Target Class
|
Readout |
Assays |
Pre-Configured Panels
|
Custom Profile |
Single Assay Technology |
Standard Turnaround |
Accelerated Turnaround |
| Bromodomain |
Competition Binding Platform |
12 |
Yes |
Yes |
Yes |
10 days |
15 days |
| GPCR |
Arrestin |
>180 |
Mutiple |
Yes |
Yes |
20 days |
10 days |
| GPCR |
cAMP |
>120 |
No |
Yes |
Yes |
20 days |
10 days |
| GPCR |
Calcium |
>40 |
No |
Yes |
Yes |
20 days |
10 days |
| GPCR |
Internalization |
>60 |
No |
Yes |
Yes |
20 days |
5 days |
| NHR |
Nuclear Translocation/ Cofactor Interaction |
>20 |
Yes |
Yes |
No |
20 days |
10 days |
| Receptor Tyrosine Kinase |
Cell-based |
>15 |
No |
Yes |
Yes |
20 days |
10 days |
| Cytokine Tyrosine Kinase |
Cell-based |
>5 |
No |
Yes |
Yes |
20 days |
10 days |
| Kinase |
in vitro |
1-451 |
Mutiple |
Yes |
Yes |
>10 days |
5 days |
| Pathway |
Cell-based |
>10 |
No |
Yes |
Multiple |
20 days |
10 days |
A novel industry leading platform for identifying small molecule bromodomain inhibitors. Based on the proven KINOME
scan℠ technology platform, BROMO
scan℠ is robust bromodomain assay panel suitable for high throughput screening that delivers quantitative ligand binding data to facilitate the identification and optimization of potent and selective small molecule bromodomain inhibitors inhibitors.
Comprehensive services for interrogating compound activity against a large range of GPCRs. Over 400 assays available for measuring arrestin recruitment, second messenger signaling and receptor internalization.
Two assay formats available for NHR signaling: Nuclear Translocation and Steroid Co-factor interaction. These cell based assays cover the majority of Nuclear Hormone receptors and provide powerful alternatives to gene reporter approaches.
A growing portfolio of cell-based assays for kinase drug discovery for receptor and cytosolic tyrosine kinases. Provides complementary cellular readout to
KINOMEscan's in vitro biochemical kinase inhibitor profiling services.
KINOMEscan is a leading provider of kinase inhibitor profiling services to the kinase drug discovery industry.
A collection of cell based tools for measuring a variety of cellular events involving signaling pathways.