Services > Panel Services > Orphan GPCR Panel

Orphan GPCR Panel

DiscoveRx Services offers a comprehensive portfolio of cell-based functional orphan GPCR assays for deorphanization and specificity determination. This panel utilizes DiscoveRx's arrestin recruitment technology to enable identification of GPCR activation regardless of G-protein coupling and is a powerful solution for identifying novel ligand and receptor pairings.
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Panel Highlights and Benefits

  • Comprehensive - more than 76 orphan GPCRs
  • Single assay readout facilitates data comparison across assays
  • Ideal for novel ligand identification & receptor de-orphanization
  • Accurate, precise & reproducible data
  • Broad applications - including de-orphanization programs and specificity determination
  • Assays performed in duplicate

Performance

  • Arrestin orphan panel successfully used to de-orphanize many GPCRs
  • 12 targets uniquely identified or verified using the arrestin platform
  • Customer validated - 11 novel target interactions identified using orphan GPCR panel
  • 27% of targets have produced hits


Summary of DiscoveRx De-orphanization Efforts

Deorphanized ligands
Graph indicates the results of DiscoveRx ligand deorphanization efforts: 12 receptors fully de-orphanized; 5 hits in profiles; 6 hits in panels; 63 no ligand identified.    

Reproducibility

The panels have been validated for exceptional reproducibility to ensure comparable results from test to test. All targets are sequence verified and correct expression confirmed by protein blot. GPCR expression is confirmed independently during panel testing.


View Panel profiling schedule>>

Orphan GPCR Panel List

Listed below are the assays currently available for screening and profiling.  Assays may be sorted by column name. Contact us if you don't see your target of interest in the list below as additional catalog assays may be available for screening and profiling as a custom service.
Family ▲Target GeneCommon NameSpeciesG protein couplingGenBank Accession #
Class A OrphanGPR55GPR55HumanUnknownNM_005683.3
Class A OrphanGPR84GPR84HumanGi/GoNM_020370
Class A OrphanGPR91SUCNR1HumanUnknownNM_033050
Class A OrphanCCRL2CCRL2HumanUnknownNM_003965
Class A OrphanGHSR1bGHSR1bHumanUnknownNM_004122
Class A OrphanGPR101GPR101HumanUnknownNM_054021
Class A OrphanGPR12GPR12HumanUnknownNM_005288
Class A OrphanGPR132GPR132HumanUnknownNM_013345
Class A OrphanGPR135GPR135HumanUnknownNM_022571
Class A OrphanGPR139GPR139HumanUnknownNM_171791
Class A OrphanGPR141GPR141HumanUnknownNM_181791
Class A OrphanGPR142GPR142HumanUnknownNM_181790
Class A OrphanGPR146GPR146HumanUnknownNM_138445
Class A OrphanGPR148GPR148HumanUnknownXM_293092
Class A OrphanGPR149GPR149HumanUnknownXM_293580
Class A OrphanGPR15GPR15HumanUnknownNM_005290.1
Class A OrphanGPR150GPR150HumanUnknownXM_209675
Class A OrphanGPR151GPR151HumanUnknownNM_194251
Class A OrphanGPR152GPR152HumanUnknownXM_352045
Class A OrphanGPR161GPR161HumanUnknownNM_153832.1
Class A OrphanGPR162GPR162HumanUnknownNM_019858
Class A OrphanGPR17GPR17HumanUnknownNM_005291
Class A OrphanGPR171GPR171HumanUnknownNM_013308
Class A OrphanGPR173GPR173HumanUnknownNM_018969
Class A OrphanGPR176GPR176HumanUnknownNM_007223
Class A OrphanGPR18GPR18HumanUnknownNM_005292
Class A OrphanGPR182GPR182HumanUnknownNM_007264
Class A OrphanGPR20GPR20HumanUnknownNM_005293
Class A OrphanGPR23LPA4HumanUnknownNM_005296
Class A OrphanGPR25GPR25HumanUnknownNM_005298
Class A OrphanGPR26GPR26HumanUnknownNM_153442
Class A OrphanGPR27GPR27HumanUnknownNM_018971
Class A OrphanGPR3GPR3HumanUnknownNM_005281
Class A OrphanGPR31GPR31HumanUnknownNM_005299
Class A OrphanGPR32GPR32HumanUnknownNM_001506
Class A OrphanGPR37EDNRBLHumanUnknownNM_005302
Class A OrphanGPR37L1GPR37L1HumanUnknownNM_004767
Class A OrphanGPR39GPR39HumanGqNM_001508
Class A OrphanGPR4GPR4HumanUnknownNM_005282
Class A OrphanGPR45GPR45HumanUnknownNM_007227
Class A OrphanGPR50GPR50HumanUnknownNM_004224
Class A OrphanGPR52GPR52HumanUnknownNM_005684
Class A OrphanGPR6GPR6HumanUnknownNM_005284
Class A OrphanGPR61GPR61HumanUnknownNM_031936
Class A OrphanGPR65GPR65HumanUnknownNM_003608
Class A OrphanGPR75GPR75HumanUnknownNM_006794
Class A OrphanGPR78GPR78HumanUnknownNM_080819
Class A OrphanGPR79GPR79HumanUnknownNM_001272
Class A OrphanGPR83GPR83HumanUnknownNM_016540
Class A OrphanGPR85GPR85HumanUnknownNM_018970
Class A OrphanGPR88GPR88HumanUnknownNM_022049
Class A OrphanLGR4LGR4HumanUnknownNM_018490
Class A OrphanLGR5LGR5HumanUnknownNM_003667
Class A OrphanLGR6LGR6HumanUnknownXM_097508
Class A OrphanMRGPRDMRGPRDHumanUnknownNM_198923
Class A OrphanMRGPREMRGPREHumanUnknownXM_171536
Class A OrphanMRGPRFMRGPRFHumanUnknownNM_145015
Class A OrphanMRGPRX1MRGPRX1HumanGqNM_147199
Class A OrphanMRGPRX4MRGPRX4HumanUnknownNM_054032
Class A OrphanOPN5OPN5HumanUnknownNM_181744.2
Class A OrphanOXGR1OXGR1HumanGqNM_080818.3
Class A OrphanP2RY8P2RY8HumanUnknownNM_178129
Class A OrphanTAAR5TAAR5HumanUnknownNM_003967.2
Class B OrphanBAI1BAI1HumanunknownNM_001702.2
Class B OrphanBAI2BAI2HumanunknownNM_001703.2
Class B OrphanBAI3BAI3HumanunknownNM_001704.2
Class B OrphanGPR123GPR123HumanUnknownNM_001083909
Class B OrphanGPR157GPR157HumanUnknownNM_024980
Class B OrphanGPR97GPR97HumanUnknownNM_170776
Estrogen (G protein coupled) receptorGPR30GPERHumanGi/Go & GsNM_001505
Hydroxycarboxylic acidGPR81HCA1HumanGi/GoNM_032554
Non-signalling 7TM chemokine-binding proteinsDARCFYHumanUnknownNM_002027
Other 7TM proteinsGPR107GPR107HumanUnknownNM_020960
Other 7TM proteinsGPR137TM7SF1HumanUnknownNM_003272
Other 7TM proteinsGPR143GPR143HumanUnknownNM_000273
Peptide P518 receptorGPR103QRFPRHumanGqNM_198179