Nuclear Hormone Receptor (NHR) Panel
DiscoveRx offers a comprehensive panel of NHR targets, perfect for specificity determination. This panel utilizes our protein-interaction technology to measures steroid cofactor recruitment to the NHR in question. This approach provides a direct readout of NHR receptor activation and does not rely on gene reporter systems.
The panels determine activity of your compounds in both agonist and antagonist mode and measure SRCP protein interaction.
Panel Highlights and Benefits
- Comprehensive - 19 targets
- Single assay readout
- Accurate, precise & reproducible data
- Ideal for ligand and inhibitor elucidation
- Excellent reproducibility
- Broad applications - including specificity & compound liability
- Agonist and antagonist modes available
Listed below are the assays currently available for screening and profiling. Assays may be sorted by column name.
Contact us if you don't see your target of interest in list below as additional catalog assays may be available for screening and profiling as a custom service.
| Target Gene ▲ | Species | GenBank Accession No | NHR |
| AR | Human | NM_000044 | X |
| ERRα | Human | NM_004451 | X |
| ERα | Human | NM_000125 | X |
| FXR | Human | NM_005123 | X |
| GR | Human | NM_000176 | X |
| LXRα | Human | NM_005693 | X |
| LXRβ | Human | NM_007121.4 | X |
| MR | Human | NM_000901 | X |
| PPARα | Human | NM_001001930 | X |
| PPARγ | Human | NM_138711 | X |
| PPARδ | Human | NM_006238 | X |
| PRα | Human | NM_000926 | X |
| PRβ | Human | NM_000926 | X |
| RARα | Human | NM_000964 | X |
| RARβ | Human | NM_000965 | X |
| RXRα | Human | NM_002957 | X |
| RXRγ | Human | NM_002957 | X |
| THRα | Human | NM_199334 | X |
| THRβ | Human | NM_000461 | X |