Services > High Throughput Screening

High Throughput Screening Services

  1. Enjoy the convenience of outsourced high-throughput screening and ready access to a portfolio of more than 600 highly validated and robust assays that can be deployed for testing against compound collections of any size. Outsource with confidence knowing that DiscoveRx's assays are performed under highly standardized conditions using best-in-class lab automation to provide exceptional assay performance and reproducible data. Save time and resources by eliminating assay development and free up internal resources to focus on other high value discovery activities.

    From single target HTS to library profiling and follow-up services, DiscoveRx has the experience, capacity and capability to rapidly and reliably deliver accurate, precise and reproducible data that ensures project timelines are met and maximizes the discovery of potent & selective lead compounds for new drug discovery programs.


    Benefits

  • Select from over 600 validated assays across multiple target classes
  • Capacity to screen more than 50,000 wells/day
  • Confirmation services available using multiple readouts
  • Identify novel chemotypes using multiple readouts for the same target
  • Accurate, precise & reproducible data
  • Free internal resources to focus on other activities
  • Selectivity services available for determining specificity and off target activity

Assay Validation & Data Uniformity

 

HTS - Vehicle tolerance
Vehicle tolerance is determined as part of the assay validation process prior to every screen [click graph to enlarge].

 

Data Uniformity
Plate uniformity data for a typical screen run in antagonist mode. Results show excellent performance with an average Z’ of 0.7, 47% inhibition for control antagonist IC50, and overall hit rate of 1.5% [click graph to enlarge].