Lead Optimization
Optimizing Leads from Lead Discovery/Hit ID
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Benefits
- Flexible: customer-designed assay panels for iterative target and off-target activity
- Measure activity and selectivity in parallel – optimize away from promiscuous compounds in real time
- Discover new target opportunities; extract maximum value from therapeutic assets
- Rapid turnaround supports L.O. and affords rapid SAR feedback
- Outsourcing frees up internal resources - focus on other high value discovery activities
Optimizing Leads from Lead Discovery/Hit ID
Lead optimization is an iterative process that involves modifying hits identified in screening campaigns to optimize several drug-like properties, including potency, selectivity, and pharmacokinetics. DiscoveRx provides a comprehensive portfolio of solutions to support ongoing lead optimization programs. Collect potency and selectivity data in parallel on a schedule that supports ongoing medicinal chemistry cycles.
Select from the largest available portfolio of targets to design custom panels for the regular measurement of target/off-target potency data during lead optimization. In parallel, monitor and optimize selectivity by screening lead compounds against full panels or design a customized panel of assays, which can be screened with accelerated data turnaround as part of an ongoing screening relationship
Add the convenience of outsourced profiling with consistent high quality data and eliminate the expense of failed experiments and costly capital equipment while freeing up internal scientists to focus on other high value discovery activities.
Services & Solutions
With several assay formats to choose from, DiscoveRx’s custom profiling service provides a flexible approach for compound profiling.
DiscoveRx offers multiple pre-selected panels run at
regularly scheduled intervals.
From single target HTS to library profiling and follow-up services, DiscoveRx can rapidly and reliably deliver accurate, precise and reproducible data that ensures project timelines are met and maximizes the discovery of potent & selective lead compounds for drug discovery programs.
Convenient outsourced services with consistent high quality data and accelerated turnaround time without the expense of failed experiments and costly capital equipment.